Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177140 | 0.86 | CYP1A2 (0.53) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12177755 | 0.81 | AURKA (0.60) | TDP1MEN1KMT2A | |
| SCHEMBL12177689 | 0.80 | AKR1B1 (0.60) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12177742 | 0.80 | PPARG (0.68) | AKR1B1PPARGMEN1KMT2A | |
| SCHEMBL12177580 | 0.80 | MGAM (0.60) | TDP1MEN1KMT2A | |
| SCHEMBL12177783 | 0.79 | MGAM (0.57) | TDP1MEN1KMT2A | |
| SCHEMBL12177280 | 0.78 | NPC1 (0.66) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL12177724 | 0.77 | ALDH1A1 (0.59) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL12177727 | 0.77 | ALDH1A1 (0.59) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL7464201 | 0.77 | CISD1 (0.71) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |