Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 11/20 | 0.33 |
| ▸ | MMP2 | P08253 | 11/20 | 0.33 |
| ▸ | MMP1 | P03956 | 10/20 | 0.33 |
| ▸ | MMP7 | P09237 | 3/20 | 0.33 |
| ▸ | ECE1 | P42892 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 6/20 | 0.32 |
| ▸ | MMP8 | P22894 | 4/20 | 0.32 |
| ▸ | MMP13 | P45452 | 3/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.31 |
| ▸ | MMP20 | O60882 | 1/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15840402 | 0.81 | METAP1 (0.35) | METAP1MMP3MMP2MMP1MMP7 | |
| SCHEMBL1215890 | 0.80 | MAOA (0.47) | METAP1CTSK | |
| SCHEMBL11972170 | 0.76 | USP2 (0.45) | MMP3MMP2MMP1MMP7ALDH1A1 | |
| SCHEMBL4676064 | 0.75 | HIF1A (0.37) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL3556829 | 0.75 | HIF1A (0.37) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL27145161 | 0.74 | CNR2 (0.36) | MMP9 | |
| SCHEMBL21543027 | 0.74 | CNR2 (0.36) | MMP9 | |
| SCHEMBL2784044 | 0.74 | CNR2 (0.36) | MMP9 | |
| SCHEMBL12884692 | 0.73 | DPP4 (0.43) | METAP1ECE1ALDH1A1LMNAMAPT | |
| SCHEMBL8690110 | 0.72 | MMP3 (0.35) | MMP3MMP2MMP1MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | CNR1, CNR2, GPR119 | METAP1 4497/4885MMP3 3964/4885MMP2 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.