Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194518 | 1.00 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL681587 | 0.95 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL681586 | 0.95 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL681290 | 0.87 | NTSR1 (0.50) | ALDH1A1KMT2AMEN1MITFSMN1; SMN2 | |
| SCHEMBL681572 | 0.87 | NTSR1 (0.50) | ALDH1A1KMT2AMEN1MITFSMN1; SMN2 | |
| SCHEMBL681213 | 0.86 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL680954 | 0.86 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL12193945 | 0.86 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL16131097 | 0.85 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KMT2AMEN1NPSR1 | |
| SCHEMBL12194517 | 0.85 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846681-B2 | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20110245230-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245230-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | TK1, PIK3CA, AKT1 | ALDH1A1 2573/4885L3MBTL1 2697/4885KMT2A 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.