Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681586 | 1.00 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL12194516 | 0.95 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL12194518 | 0.95 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL681572 | 0.88 | NTSR1 (0.50) | ALDH1A1KMT2AMEN1NTSR1MITF | |
| SCHEMBL681290 | 0.88 | NTSR1 (0.50) | ALDH1A1KMT2AMEN1NTSR1MITF | |
| SCHEMBL680792 | 0.88 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL681233 | 0.88 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL12188386 | 0.85 | PAX8 (0.52) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL12188383 | 0.85 | PAX8 (0.52) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 | |
| SCHEMBL2738454 | 0.82 | NTSR1 (0.48) | ALDH1A1L3MBTL1KMT2AMEN1NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |