Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681290 | 1.00 | NTSR1 (0.50) | NTSR1USP2ALOX15POLBTSHR | |
| SCHEMBL12194517 | 0.89 | ALDH1A1 (0.44) | NTSR1POLBTSHRSLC6A2ALDH1A1 | |
| SCHEMBL16131097 | 0.89 | ALDH1A1 (0.44) | NTSR1POLBTSHRSLC6A2ALDH1A1 | |
| SCHEMBL681587 | 0.88 | ALDH1A1 (0.46) | NTSR1MITFALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL681586 | 0.88 | ALDH1A1 (0.46) | NTSR1MITFALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12194516 | 0.87 | ALDH1A1 (0.50) | NTSR1MITFALDH1A1HTTATM | |
| SCHEMBL12194518 | 0.87 | ALDH1A1 (0.50) | NTSR1MITFALDH1A1HTTATM | |
| SCHEMBL12194515 | 0.87 | MC4R (0.46) | NTSR1USP2POLBTSHRSLC6A2 | |
| SCHEMBL681136 | 0.86 | HSD11B1 (0.44) | NTSR1ALOX15TSHRMC4RSIGMAR1 | |
| SCHEMBL681765 | 0.86 | HSD11B1 (0.44) | NTSR1ALOX15TSHRMC4RSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |