Sugi Predict

Sugi Predict / Compounds / SCHEMBL12199526

SCHEMBL12199526

SCHEMBL12199526

COC(=O)CC(=O)OC1COC(c2ccccc2)OC1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HCRTR2 O43614 1/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ ACHE P22303 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ MAPT P10636 3/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ BCHE P06276 2/20 0.36
▸ POLB P06746 1/20 0.36
▸ ATM Q13315 1/20 0.35
▸ BRD4 O60885 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12199530 0.88 MEN1 (0.39) HCRTR2MEN1KMT2AL3MBTL1CYP2C19
SCHEMBL14038138 0.85 MEN1 (0.41) HCRTR2MEN1KMT2ACYP2C19MAPT
SCHEMBL13278373 0.85 MEN1 (0.41) HCRTR2MEN1KMT2ACYP2C19MAPT
SCHEMBL12199634 0.84 MEN1 (0.40) HCRTR2MEN1KMT2AL3MBTL1CYP2C19
SCHEMBL19328433 0.83 MEN1 (0.44) HCRTR2MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL19543487 0.82 GAA (0.38) HCRTR2MEN1KMT2AL3MBTL1CYP2C19
SCHEMBL6033370 0.81 TBXA2R (0.39) HCRTR2MEN1KMT2ACYP2C19MAPT
SCHEMBL5052675 0.81 TBXA2R (0.39) HCRTR2MEN1KMT2ACYP2C19MAPT
SCHEMBL12199639 0.81 SLC18A3 (0.41) HCRTR2MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL12199520 0.80 SLC18A3 (0.43) HCRTR2MEN1KMT2AL3MBTL1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9408919-B2 Biodegradable polymer—bioactive moiety conjugates POLYACTIVA PTY LTD. (AU) 2016-08-09 — — US disclosed
US-20140120058-A1 POLYMER CONJUGATED PROSTAGLANDIN ANALOGUES POLYACTIVA PTY LTD 2014-05-01 — — US disclosed
US-20140046018-A1 BIODEGRADABLE POLYMER - BIOACTIVE MOIETY CONJUGATES POLYACTIVA PTY LTD. (AU) 2014-02-13 — — US disclosed
US-8535655-B2 Biodegradable polymer—bioactive moiety conjugates POLYACTIVA PTY LTD. (AU) 2013-09-17 — — US disclosed
US-20110243884-A1 BIODEGRADABLE POLYMER - BIOACTIVE MOIETY CONJUGATES THE BIONICS INSTITUTE OF AUSTRALIA (AU) 2011-10-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140046018-A1 BIODEGRADABLE POLYMER - BIOACTIVE MOIETY CONJUGATES BMP2, MKI67, FGF2 HCRTR2 3966/4885MEN1 1026/4885KMT2A 3711/4885
US-20110243884-A1 BIODEGRADABLE POLYMER - BIOACTIVE MOIETY CONJUGATES BMP2, MKI67, FGF2 HCRTR2 3966/4885MEN1 1026/4885KMT2A 3711/4885
US-20140120058-A1 POLYMER CONJUGATED PROSTAGLANDIN ANALOGUES PTGIS, PTGS2, PTGES HCRTR2 3103/4885MEN1 3369/4885KMT2A 3825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.