SCHEMBL12201811

SCHEMBL12201811

CCOC(=O)C(C)CC1CCC(F)(F)CC1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.35
CYP2C19 P33261 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
GAA P10253 1/20 0.34
NAAA Q02083 1/20 0.33
ASAH1 Q13510 1/20 0.33
CYP2D6 P10635 1/20 0.33
METAP2 P50579 2/20 0.32
TRPM8 Q7Z2W7 1/20 0.32
JAK2 O60674 1/20 0.31
JAK1 P23458 1/20 0.31
TYK2 P29597 1/20 0.31
JAK3 P52333 1/20 0.31
P2RX3 P56373 1/20 0.31
ALDH1A1 P00352 2/20 0.31
TRPA1 O75762 1/20 0.31
MAPT P10636 1/20 0.30
GCK P35557 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2669320 0.84 METAP2 (0.35) L3MBTL1GAANAAAASAH1CYP2D6
SCHEMBL13889046 0.81 METAP2 (0.45) L3MBTL1METAP2ALDH1A1
SCHEMBL21564359 0.78 CPN1 (0.44) CYP3A4CYP2C19L3MBTL1GAAMAPT
SCHEMBL27939502 0.77 JAK2 (0.31) NAAAASAH1JAK2JAK1TYK2
Hydrochloric Acid SCHEMBL29890856 0.77 CPN1 (0.42) CYP3A4CYP2C19L3MBTL1GAAMAPT
SCHEMBL16699708 0.76 L3MBTL1 (0.39) L3MBTL1TRPM8ALDH1A1TRPA1MAPT
SCHEMBL31547128 0.76 L3MBTL1 (0.39) L3MBTL1TRPM8ALDH1A1TRPA1MAPT
SCHEMBL2778453 0.76 TRPA1 (0.41) L3MBTL1GAANAAAASAH1CYP2D6
SCHEMBL18082618 0.75 SMN1; SMN2 (0.33) NAAAASAH1ALDH1A1
SCHEMBL4599733 0.74 CYP3A4 (0.42) CYP3A4CYP2C19L3MBTL1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8034822-B2 Glucokinase activators TAKEDA SAN DIEGO, INC. (US) 2011-10-11 US disclosed