SCHEMBL12201833

SCHEMBL12201833

CNC(=O)Cc1ccccc1-c1cc(C)cc(F)c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.41
CNR2 P34972 2/20 0.41
RAB9A P51151 2/20 0.39
LMNA P02545 2/20 0.39
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 3/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
KDM4E B2RXH2 2/20 0.35
PPIA P62937 1/20 0.34
PDK2 Q15119 2/20 0.34
KMT2A Q03164 1/20 0.34
HPGD P15428 1/20 0.34
PTGS2 P35354 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2393439 0.83 SMN1; SMN2 (0.46) RAB9ALMNASMN1; SMN2CHRM1CHRM3
SCHEMBL9890753 0.83 RXRA (0.46) RAB9ALMNAPDK2
SCHEMBL2394292 0.82 FFAR1 (0.47) CNR2LMNAALDH1A1CHRM1CHRM3
SCHEMBL2391383 0.81 SLC6A4 (0.49) RAB9ALMNASMN1; SMN2ALDH1A1KMT2A
SCHEMBL2397419 0.78 KMT2A (0.51) RAB9ALMNAHDAC3HDAC1HDAC2
SCHEMBL9890755 0.77 GRIN1 (0.42) RAB9ALMNASMN1; SMN2ALDH1A1KMT2A
SCHEMBL9890752 0.77 SMN1; SMN2 (0.42) RAB9ALMNASMN1; SMN2ALDH1A1KMT2A
SCHEMBL2395314 0.75 RAB9A (0.49) RAB9ALMNASMN1; SMN2ALDH1A1KDM4E
SCHEMBL12201835 0.73 SMN1; SMN2 (0.42) RAB9ALMNASMN1; SMN2ALDH1A1KDM4E
SCHEMBL9890731 0.73 LMNA (0.48) RAB9ALMNASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2374790-A1 BIPHENYLACETAMIDE DERIVATIVE Dainippon Sumitomo Pharma Co., Ltd. (JP) 2011-10-12 EP disclosed