Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12202110 | 0.87 | CYP4F2 (0.38) | CYP4F2CYP4A11NLRP3LMNAALDH1A1 | |
| SCHEMBL10134595 | 0.81 | MGLL (0.36) | CYP4F2CYP4A11NLRP3ALDH1A1KDM4E | |
| SCHEMBL13265233 | 0.81 | CYP4F2 (0.55) | CYP4F2CYP4A11NLRP3LMNAALDH1A1 | |
| SCHEMBL2556229 | 0.79 | CYP4F2 (0.53) | CYP4F2CYP4A11NLRP3ALDH1A1KDM4E | |
| SCHEMBL13265232 | 0.79 | CYP4F2 (0.40) | CYP4F2CYP4A11LMNAALDH1A1KDM4E | |
| SCHEMBL12202857 | 0.75 | CYP4F2 (0.39) | CYP4F2CYP4A11NLRP3LMNAALDH1A1 | |
| SCHEMBL12202109 | 0.74 | CYP4F2 (0.38) | CYP4F2CYP4A11NLRP3LMNAALDH1A1 | |
| SCHEMBL27713100 | 0.73 | CYP4F2 (0.47) | CYP4F2CYP4A11NLRP3ALDH1A1KDM4E | |
| SCHEMBL14824605 | 0.73 | CASP1 (0.39) | CYP4F2CYP4A11NLRP3ALDH1A1KDM4E | |
| SCHEMBL13265179 | 0.73 | ALDH1A1 (0.40) | CYP4F2CYP4A11NLRP3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374794-B1 | CYCLIC AMINE COMPOUNDS | DAIICHI SANKYO CO LTD (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2374794-A1 | CYCLIC AMINE COMPOUNDS | Daiichi Sankyo Company, Limited (JP) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010074088-A1 | CYCLIC AMINE COMPOUNDS | 第一三共株式会社 (JP) | 2010-07-01 | — | — | WO | disclosed |