Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13530564 | 0.79 | METAP1 (0.44) | L3MBTL1APPLMNAHTTEGFR | |
| SCHEMBL13530842 | 0.79 | KDM4E (0.42) | L3MBTL1LMNASIRT5KDM4EKMT2A | |
| SCHEMBL13530563 | 0.76 | METAP1 (0.40) | L3MBTL1APPLMNAHTTEGFR | |
| SCHEMBL655263 | 0.75 | ULK1 (0.57) | HTTSIRT5RAB9A | |
| SCHEMBL13530852 | 0.75 | AURKA (0.40) | LMNASIRT5KDM4EHDAC6ALDH1A1 | |
| SCHEMBL13530508 | 0.75 | F2 (0.46) | L3MBTL1LMNAMAPK1METAP1METAP2 | |
| SCHEMBL1224382 | 0.75 | KDM4E (0.50) | L3MBTL1EGFRKDM4EKMT2AMEN1 | |
| SCHEMBL6016288 | 0.74 | RAB9A (0.51) | L3MBTL1APPHTTKMT2AALDH1A1 | |
| SCHEMBL13530893 | 0.73 | KMT2A (0.48) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL13530612 | 0.73 | BCHE (0.47) | APPLMNAHTTMAPK1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519512-B1 | N1-ACYL- 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD (IL) | 2019-03-20 | — | — | EP | disclosed |
| US-9204653-B2 | 5-fluoro pyrimidine derivatives | DOW AGROSCIENCES LLC (US) | 2015-12-08 | — | — | US | disclosed |
| EP-2462133-B1 | 5-FLUORO-2-OXOPYRIMIDINE- 1(2H)-CARBOXYLATE DERIVATIVES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20140024616-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2014-01-23 | — | — | US | disclosed |
| US-8470839-B2 | N1-acyl-5-fluoropyrimidinone derivatives | DOW AGROSCIENCES, LLC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8318758-B2 | 5-fluoro-2-oxopyrimidine-1(2H)-carboxylate derivatives | DOW AGROSCIENCES, LLC (US) | 2012-11-27 | — | — | US | disclosed |
| EP-2519512-A1 | N1-ACYL- 5-FLUOROPYRIMIDINONE DERIVATIVES | Dow AgroSciences LLC (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-2462133-A1 | 5-FLUORO-2-OXOPYRIMIDINE- 1(2H)-CARBOXYLATE DERIVATIVES | Dow AgroSciences LLC (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017544-A1 | 5-FLUORO-2-OXOPYRIMIDINE- 1(2H)-CARBOXYLATE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20110034490-A1 | N1-acyl-5-fluoropyrimidinone derivatives | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034491-A1 | 5-FLUORO-2-OXOPYRIMIDINE- 1(2H)-CARBOXYLATE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2011-02-10 | — | — | US | disclosed |
| WO-2011017538-A1 | N1-ACYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20100022538-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022538-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DPYD, DPM1, DDX5 | L3MBTL1 896/4885APP 4696/4885LMNA 4636/4885 |
| US-20140024616-A1 | 5-FLUORO PYRIMIDINE DERIVATIVES | DPYD, DPM1, DDX5 | L3MBTL1 896/4885APP 4696/4885LMNA 4636/4885 |
| US-20110034490-A1 | N1-acyl-5-fluoropyrimidinone derivatives | NANP, NAT1, AKR7A2 | L3MBTL1 556/4885APP 4173/4885LMNA 3426/4885 |
| US-20110034491-A1 | 5-FLUORO-2-OXOPYRIMIDINE- 1(2H)-CARBOXYLATE DERIVATIVES | DDT, PFAS, CASP2 | L3MBTL1 581/4885APP 4847/4885LMNA 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.