Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13530879 | 0.82 | ROCK2 (0.53) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL1225198 | 0.79 | ADORA3 (0.50) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL12884145 | 0.78 | MAPK1 (0.51) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL12884137 | 0.77 | ADORA3 (0.48) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL12884139 | 0.77 | ADORA3 (0.48) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL13529782 | 0.76 | KMT2A (0.53) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL12884141 | 0.75 | ADORA3 (0.46) | ROCK2ADORA3KMT2AMEN1HPGD | |
| SCHEMBL27406221 | 0.71 | MAPT (0.64) | KMT2AMEN1HPGDALDH1A1TDP1 | |
| SCHEMBL20540167 | 0.71 | KMT2A (0.61) | KMT2AMEN1HPGDALDH1A1GAA | |
| SCHEMBL23083281 | 0.71 | NPC1 (0.72) | KMT2AMEN1HPGDALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2461686-B1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2015-10-07 | — | — | EP | disclosed |
| US-9000002-B2 | N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000002-B2 | N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000002-B2 | N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-20140011824-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2014-01-09 | — | — | US | disclosed |
| US-20140011824-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2014-01-09 | — | — | US | disclosed |
| US-20140011824-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2014-01-09 | — | — | US | disclosed |
| US-8552020-B2 | N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives | DOW AGROSCIENCES, LLC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552020-B2 | N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives | DOW AGROSCIENCES, LLC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552020-B2 | N1-substituted-5-fluoro-2-oxopyrimidinone-1(2H)-carboxamide derivatives | DOW AGROSCIENCES, LLC. (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2461686-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | Dow AgroSciences LLC (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017545-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2011017545-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20110034492-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034492-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034492-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034492-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DDT, CASP2, GDI1 | ROCK2 2332/4885ADORA3 1844/4885KMT2A 1216/4885 |
| US-20140011824-A1 | N1-SUBSTITUTED-5-FLUORO-2-OXOPYRIMIDINONE-1(2H)-CARBOXAMIDE DERIVATIVES | DDT, CASP2, GDI1 | ROCK2 2332/4885ADORA3 1844/4885KMT2A 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.