SCHEMBL12246744

SCHEMBL12246744

COc1ccc(CCNC(=O)/C=C/c2ccc(O)c(C)c2)cc1OC

nearest known ligand 0.76

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.76
TYR P14679 2/20 0.71
ACHE P22303 1/20 0.71
ALDH1A1 P00352 2/20 0.69
KDM4E B2RXH2 1/20 0.69
PKM P14618 1/20 0.69
LMNA P02545 2/20 0.69
HPGD P15428 1/20 0.69
HTT P42858 1/20 0.69
MAOA P21397 1/20 0.65
MAOB P27338 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.64
APP P05067 1/20 0.62
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
OPRM1 P35372 1/20 0.60
OPRD1 P41143 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16382867 0.91 ACHE (0.81) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL12246741 0.91 ACHE (0.81) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL12299133 0.91 TYR (0.85) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL17956819 0.91 TYR (0.85) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL17956820 0.91 TYR (0.85) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL1917252 0.90 MAPT (0.84) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL32679236 0.90 MAPT (0.84) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL4812487 0.90 MAPT (0.84) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL1917292 0.90 MAPT (0.84) MAPTTYRACHEALDH1A1KDM4E
SCHEMBL32679235 0.90 MAPT (0.84) MAPTTYRACHEALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9089499-B2 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions UNIVERSITE JOSEPH FOURIER-GRENOBLE 1 (FR) 2015-07-28 US disclosed
US-20130272983-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and their Use in Cosmetic or Dermatological Compositions Universite Joseph Fourier-Grenoble 1. (FR) 2013-10-17 US disclosed
US-8481593-B2 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions BASF BEAUTY CARE SOLUTIONS S.A.S. (FR) 2013-07-09 US disclosed
US-20110237551-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use in Cosmetic or Dermatological Compositions BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2011-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237551-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use in Cosmetic or Dermatological Compositions TYR, CUTA, HPD MAPT 3126/4885TYR 1/4885ACHE 1052/4885
US-20130272983-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and their Use in Cosmetic or Dermatological Compositions TYR, CUTA, HPD MAPT 3115/4885TYR 1/4885ACHE 1070/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.