SCHEMBL4812487

SCHEMBL4812487

COc1ccc(C=CC(=O)NCCc2ccc(OC)c(OC)c2)cc1OC

nearest known ligand 0.84

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.84
ALDH1A1 P00352 4/20 0.84
KDM4E B2RXH2 3/20 0.84
PKM P14618 2/20 0.84
LMNA P02545 2/20 0.79
HPGD P15428 1/20 0.79
HTT P42858 1/20 0.79
TYR P14679 1/20 0.74
ACHE P22303 1/20 0.74
SMN1; SMN2 Q16637 1/20 0.74
KMT2A Q03164 3/20 0.69
MEN1 O00255 2/20 0.69
OPRM1 P35372 1/20 0.69
OPRD1 P41143 1/20 0.69
MAOA P21397 1/20 0.67
MAOB P27338 1/20 0.67
CNR2 P34972 1/20 0.67
POLB P06746 1/20 0.65
ALOX5 P09917 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32679235 1.00 MAPT (0.84) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL32679236 1.00 MAPT (0.84) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL29357137 1.00 MAPT (0.84) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL31286546 1.00 MAPT (0.84) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL1917292 1.00 MAPT (0.84) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL1917252 1.00 MAPT (0.84) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL17956819 0.94 TYR (0.85) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL17956820 0.94 TYR (0.85) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL12299133 0.94 TYR (0.85) MAPTALDH1A1KDM4EPKMLMNA
SCHEMBL16382867 0.92 ACHE (0.81) MAPTALDH1A1KDM4EPKMLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3050971-A1 Process for the enzymatic production of 3,4-O-dimethylated cinnamic acids, 3,4-dimethoxyphenylethylamines and 4-O-methylated cinnamic acid amides Symrise AG (DE) 2016-08-03 EP claimed
EP-1774954-B1 Mouthwash and dentifrice and cleansing composition HENKEL AG & CO KGAA (DE) 2014-08-13 EP claimed
US-7378121-B2 Use of ferulic acid amides as flavor compounds SYMRISE GMBH & CO. KG (DE) 2008-05-27 US claimed
EP-1323356-B1 Use of ferulic amides as flavouring agents SYMRISE GMBH & CO KG (DE) 2006-03-15 EP claimed
US-20030152682-A1 Use of ferulic acid amides as flavor compounds SYMRISE AG (DE) 2003-08-14 US claimed
EP-4359496-A1 AROMA OR FRAGRANCE COMPOSITIONS, COMPRISING 4-METHYLHEPTAN-3-ONE, AND METHODS FOR PRODUCING THEM Symrise AG (DE) 2024-05-01 EP disclosed
EP-3585185-B1 METHOD FOR PRODUCING ROTUNDONE-CONTAINING MIXTURES SYMRISE AG (DE) 2024-04-10 EP disclosed
US-20240108040-A1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2024-04-04 US disclosed
US-11758933-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2023-09-19 US disclosed
WO-2022268285-A1 AROMA OR FRAGRANCE COMPOSITIONS, COMPRISING 4-METHYLHEPTAN-3-ONE, AND METHODS FOR PRODUCING THEM SYMRISE AG (DE) 2022-12-29 WO disclosed
EP-3368542-B1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2022-06-22 EP disclosed
US-11357246-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2022-06-14 US disclosed
US-20160067169-A1 TOOTHPASTE CONTAINING FLUORIDE AND POLYLACTIC ACID PARTICLES HENKEL AG & CO. KGAA (DE) 2016-03-10 US disclosed
US-20160067170-A1 ORAL AND DENTAL HYGIENE AND CLEANING AGENTS WITH IMPROVED ANTI-BACTERIAL ACTION HENKEL AG & CO. KGAA (DE) 2016-03-10 US disclosed
US-20160067168-A1 ORAL AND DENTAL HYGIENE AND CLEANING AGENTS FOR SENSITIVE TEETH HENKEL AG & CO. KGAA (DE) 2016-03-10 US disclosed
US-20160067171-A1 ORAL AND DENTAL HYGIENE AND CLEANING AGENTS WITH OPTIMIZED TASTE HENKEL AG & CO. KGAA (DE) 2016-03-10 US disclosed
US-7378121-B2 Use of ferulic acid amides as flavor compounds SYMRISE GMBH & CO. KG (DE) 2008-05-27 US disclosed
US-20080038386-A1 Use of a liquid cooling sensate to provide a pungent, warming or tingling sensate composition MOZA ASHOK K 2008-02-14 US disclosed
US-20030152682-A1 Use of ferulic acid amides as flavor compounds SYMRISE AG (DE) 2003-08-14 US disclosed
EP-1323356-A2 Use of ferulic amides as flavouring agents HAARMANN & REIMER GMBH (DE) 2003-07-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240108040-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 MAPT 4340/4885ALDH1A1 978/4885KDM4E 3699/4885
US-20160067170-A1 ORAL AND DENTAL HYGIENE AND CLEANING AGENTS WITH IMPROVED ANTI-BACTERIAL ACTION USP39, USP30, SOD1 MAPT 3528/4885ALDH1A1 2594/4885KDM4E 2363/4885
US-20160067168-A1 ORAL AND DENTAL HYGIENE AND CLEANING AGENTS FOR SENSITIVE TEETH SI, H1-0, POLD1 MAPT 4078/4885ALDH1A1 2622/4885KDM4E 3765/4885
US-11357246-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 MAPT 4340/4885ALDH1A1 978/4885KDM4E 3699/4885
US-20160067171-A1 ORAL AND DENTAL HYGIENE AND CLEANING AGENTS WITH OPTIMIZED TASTE SORD, TAS2R40, TREH MAPT 1695/4885ALDH1A1 1851/4885KDM4E 2052/4885
US-20160067169-A1 TOOTHPASTE CONTAINING FLUORIDE AND POLYLACTIC ACID PARTICLES PUF60, POLI, FIP1L1 MAPT 1349/4885ALDH1A1 4168/4885KDM4E 2879/4885
US-11758933-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 MAPT 4340/4885ALDH1A1 978/4885KDM4E 3699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.