Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.55 |
| ▸ | KDM5C | P41229 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | KDM4A | O75164 | 5/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.55 |
| ▸ | KDM6B | O15054 | 4/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.55 |
| ▸ | KDM3A | Q9Y4C1 | 4/20 | 0.55 |
| ▸ | KDM5A | P29375 | 3/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.55 |
| ▸ | TET3 | O43151 | 1/20 | 0.55 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ASPH | Q12797 | 1/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.55 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.55 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.55 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.55 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31191238 | 1.00 | KDM4C (0.55) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL481039 | 0.85 | KDM4C (0.52) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL5559240 | 0.85 | CYP1A2 (0.40) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| Hydrochloric Acid SCHEMBL4774803 | 0.83 | CYP1A2 (0.39) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL12640033 | 0.83 | CYP1A2 (0.42) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL5566822 | 0.83 | CYP1A2 (0.46) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL7670706 | 0.82 | KDM4C (0.57) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL2305108 | 0.82 | KDM4C (0.57) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL12252467 | 0.81 | GABRP (0.58) | KDM4CKDM5CKDM4EKDM4AKDM5B | |
| SCHEMBL1647272 | 0.81 | CYP1A2 (0.61) | KDM4CKDM5CKDM4EKDM4AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200247798-A1 | THERAPEUTIC AGENT FOR ANXIETY DISORDERS | KYOWA KIRIN CO LTD (JP) | 2020-08-06 | — | — | US | disclosed |
| US-10407440-B2 | Therapeutic agent for motor disorders | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2019-09-10 | — | — | US | disclosed |
| EP-3478676-A1 | BENZODIOXANE DERIVATIVES AND THEIR PHARMACEUTICAL USE | Orion Corporation (FI) | 2019-05-08 | — | — | EP | disclosed |
| EP-3378860-A1 | THERAPEUTIC AGENT FOR MOTOR DISORDERS | Kyowa Hakko Kirin Co., Ltd. (JP) | 2018-09-26 | — | — | EP | disclosed |
| EP-2433938-B1 | THERAPEUTIC AGENT FOR MOTOR DISORDERS | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-04-18 | — | — | EP | disclosed |
| CN-104606190-B | Agent for treating involuntary movement | 协和发酵麒麟株式会社 | 2018-01-19 | — | — | CN | disclosed |
| WO-2018002437-A1 | BENZODIOXANE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ORION CORPORATION (FI) | 2018-01-04 | — | — | WO | disclosed |
| US-20170275296-A1 | THERAPEUTIC AGENT FOR MOTOR DISORDERS | KYOWA KIRIN CO., LTD. (JP) | 2017-09-28 | — | — | US | disclosed |
| US-9714257-B2 | Therapeutic agent for motor disorders | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-07-25 | — | — | US | disclosed |
| EP-2474544-B1 | THERAPEUTIC AGENT FOR ANXIETY DISORDERS | KYOWA HAKKO KIRIN CO LTD (JP) | 2017-07-12 | — | — | EP | disclosed |
| US-6992083-B2 | deiodination/arylation, acylation or hydrogenation of a substituted 4-methoxy-bezoxazole derivative; adenosine receptor ligands; Parkinson's and Alzheimer's Diseases; 2-Chloromethyl-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide | HOFFMAN-LA ROCHE INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-1615919-A1 | 7-([1,4]DIOXAN-2-YL)-BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-18 | — | — | EP | disclosed |
| EP-1587799-A1 | BENZOXAZOLE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-26 | — | — | EP | disclosed |
| US-6872833-B2 | Adenosine receptor ligands | HOFFMANN-LA ROCHE INC. (US) | 2005-03-29 | — | — | US | disclosed |
| WO-2005000842-A1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMAN-LA ROCHE AG (CH) | 2005-01-06 | — | — | WO | disclosed |
| US-20040235915-A1 | Benzothiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | US | disclosed |
| WO-2004089949-A1 | 7-([1,4]DIOXAN-2-YL)-BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204584-A1 | ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-14 | — | — | US | disclosed |
| US-20040152702-A1 | Benzoxazol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-05 | — | — | US | disclosed |
| WO-2004063177-A1 | BENZOXAZOLE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152702-A1 | Benzoxazol derivatives | P2RX3, P2RX2, P2RX1 | KDM4C 2406/4885KDM5C 2407/4885KDM4E 2939/4885 |
| US-10407440-B2 | Therapeutic agent for motor disorders | DDT, COMT, SLC6A3 | KDM4C 4809/4885KDM5C 4811/4885KDM4E 4721/4885 |
| US-20040235915-A1 | Benzothiazole derivatives | ADORA1, ADORA2A, ADORA3 | KDM4C 4188/4885KDM5C 3907/4885KDM4E 2640/4885 |
| US-20040204584-A1 | ADENOSINE RECEPTOR LIGANDS | ADORA1, ADORA2A, ADORA3 | KDM4C 4701/4885KDM5C 4283/4885KDM4E 4368/4885 |
| US-20170275296-A1 | THERAPEUTIC AGENT FOR MOTOR DISORDERS | DDT, COMT, SLC6A3 | KDM4C 4809/4885KDM5C 4811/4885KDM4E 4721/4885 |
| US-20200247798-A1 | THERAPEUTIC AGENT FOR ANXIETY DISORDERS | TAAR1, SLC6A1, GABBR1 | KDM4C 4107/4885KDM5C 4465/4885KDM4E 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.