Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225817 | 1.00 | RAB9A (0.48) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1224684 | 0.90 | LMNA (0.45) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1224685 | 0.90 | LMNA (0.45) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1225682 | 0.83 | LMNA (0.43) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1225680 | 0.83 | LMNA (0.43) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27816293 | 0.81 | HCAR2 (0.47) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2162202 | 0.81 | KMT2A (0.58) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2162205 | 0.81 | KMT2A (0.58) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7079542 | 0.80 | ELANE (0.37) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7079546 | 0.80 | ELANE (0.37) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193177-B2 | Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases | ANGION BIOMEDICA CORP. (US) | 2012-06-05 | — | — | US | claimed |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. | 2010-10-07 | — | — | US | claimed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | claimed |
| US-6610726-B2 | Pyrazole derivative that mimics or agonizes hepatocyte growth factor/scatter factor; antiischemic agents | NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE | 2003-08-26 | — | — | US | claimed |
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM | 2003-03-06 | — | — | US | claimed |
| US-20030022924-A1 | Compositions and agents for modulating cellular proliferation and angiogenesis | PILLARISETTI SIVARAM (US) | 2003-01-30 | — | — | US | claimed |
| US-7879898-B1 | treating a chronic obstructive pulmonary disease using modulators of HGF/SF activity; for example, 3-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one; emphysema | ANGION BIOMEDICA CORP. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | PILLARISETTI SIVARAM (US) | 2005-05-05 | — | — | US | disclosed |
| US-6855728-B2 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM (US) | 2005-02-15 | — | — | US | disclosed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | disclosed |
| US-6610726-B2 | Pyrazole derivative that mimics or agonizes hepatocyte growth factor/scatter factor; antiischemic agents | NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE | 2003-08-26 | — | — | US | disclosed |
| US-20030022924-A1 | Compositions and agents for modulating cellular proliferation and angiogenesis | PILLARISETTI SIVARAM (US) | 2003-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | RAB9A 4231/4885ALDH1A1 510/4885MEN1 3250/4885 |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | RAB9A 4231/4885ALDH1A1 510/4885MEN1 3250/4885 |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | HGF, HDGF, MET | RAB9A 4231/4885ALDH1A1 510/4885MEN1 3250/4885 |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | HGF, HDGF, HGFAC | RAB9A 3231/4885ALDH1A1 1992/4885MEN1 2880/4885 |
| US-20030022924-A1 | Compositions and agents for modulating cellular proliferation and angiogenesis | HGF, HDGF, MET | RAB9A 3636/4885ALDH1A1 644/4885MEN1 3464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.