SCHEMBL12259683

SCHEMBL12259683

COc1cc(OC)c2cc(C(C)C)c3c(c2c1)OC(c1ccccc1)(c1ccc(N(C)C)cc1)C=C3

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.34
KMT2A Q03164 5/20 0.34
TDP1 Q9NUW8 4/20 0.31
MAPK1 P28482 3/20 0.31
KDM1A O60341 1/20 0.31
MAPT P10636 2/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
USP2 O75604 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C9 P11712 1/20 0.30
ALOX15 P16050 1/20 0.30
CYP2C19 P33261 1/20 0.30
BLM P54132 1/20 0.30
HSD17B10 Q99714 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12347484 0.89 EIF4A1 (0.35) MEN1KMT2AALDH1A1LMNACYP2C9
SCHEMBL7525851 0.89 TDP1 (0.32) MEN1KMT2ATDP1MAPK1KDM1A
SCHEMBL18696159 0.87 MEN1 (0.31) MEN1KMT2AKDM1A
SCHEMBL13898436 0.87 EIF4A1 (0.31)
SCHEMBL7568969 0.85 PTPN1 (0.34) MEN1KMT2ATDP1MAPK1KDM1A
SCHEMBL7566030 0.84 TDP1 (0.31) MEN1KMT2ATDP1MAPK1MAPT
SCHEMBL7528138 0.84 MEN1 (0.33) MEN1KMT2ATDP1MAPK1MAPT
SCHEMBL6131956 0.82 SLC2A1 (0.35) MEN1KMT2ATDP1MAPK1MAPT
SCHEMBL7569354 0.81 TDP1 (0.35) MEN1KMT2ATDP1MAPK1MAPT
SCHEMBL12952370 0.81 TDP1 (0.33) MEN1KMT2ATDP1MAPK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE46357-E1 Photochromic film, photochromic lens comprising the same, and method of manufacturing photochromic lens HOYA CORPORATION (JP) 2017-04-04 US disclosed
US-8852737-B2 Coating composition and photochromic optical article TOKUYAMA CORPORATION (JP) 2014-10-07 US disclosed
US-8852737-B2 Coating composition and photochromic optical article TOKUYAMA CORPORATION (JP) 2014-10-07 US disclosed
US-8557377-B2 Photochromic optical element TOKUYAMA CORPORATION (JP) 2013-10-15 US disclosed
US-8557377-B2 Photochromic optical element TOKUYAMA CORPORATION (JP) 2013-10-15 US disclosed
US-20130142948-A1 PHOTOCHROMIC LENS MANUFACTURING SYSTEM, PHOTOCHROMIC LENS MANUFACTURING DEVICE, PHOTOCHROMIC LENS MANUFACTURING PROGRAM, RECORDING MEDIUM HAVING PHOTOCHROMIC LENS MANUFACTURING PROGRAM RECORDED THEREUPON, AND PHOTOCHROMIC LENS MANUFACTURING METHOD HOYA CORPORATION (JP) 2013-06-06 US disclosed
US-8012588-B2 Layered product, optical part, processes for producing these, and coating fluid TOKUYAMA CORPORATION (JP) 2011-09-06 US disclosed
US-8012588-B2 Layered product, optical part, processes for producing these, and coating fluid TOKUYAMA CORPORATION (JP) 2011-09-06 US disclosed
US-7999989-B2 Photochromic film, photochromic lens comprising the same, and method of manufacturing photochromic lens HOYA CORPORATION (JP) 2011-08-16 US disclosed
US-20100233485-A1 Photochromic Optical Element TOKUYAMA CORPORATION (JP) 2010-09-16 US disclosed
US-20090316246-A1 PHOTOCHROMIC FILM, PHOTOCHROMIC LENS COMPRISING THE SAME, AND METHOD OF MANUFACTURING PHOTOCHROMIC LENS HOYA CORPORATION (JP) 2009-12-24 US disclosed
US-7441893-B2 Layered product and method of producing the same TOKUYAMA CORPORATION (JP) 2008-10-28 US disclosed
US-7441893-B2 Layered product and method of producing the same TOKUYAMA CORPORATION (JP) 2008-10-28 US disclosed
US-7442734-B2 Coating composition and optical article TOKUYAMA CORPORATION (JP) 2008-10-28 US disclosed
US-7442734-B2 Coating composition and optical article TOKUYAMA CORPORATION (JP) 2008-10-28 US disclosed
EP-1932882-A1 HARDENABLE COMPOSITION AND OPTICAL MEMBER MAKING USE OF THE SAME Hoya Corporation (JP) 2008-06-18 EP disclosed
US-20070127133-A1 Layered product and method of producing the same TOKUYAMA CORPORATION (JP) 2007-06-07 US disclosed
US-20070127133-A1 Layered product and method of producing the same TOKUYAMA CORPORATION (JP) 2007-06-07 US disclosed
US-7169941-B2 Photochromic composition TOKUYAMA CORPORATION (JP) 2007-01-30 US disclosed
US-7169941-B2 Photochromic composition TOKUYAMA CORPORATION (JP) 2007-01-30 US disclosed