SCHEMBL7568969

SCHEMBL7568969

COc1cc(OC)c2cc(CO)c3c(c2c1)OC(c1ccccc1)(c1ccc(N(C)C)cc1)C=C3

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.34
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
LMNA P02545 4/20 0.34
CYP1A2 P05177 3/20 0.34
CYP3A4 P08684 3/20 0.34
CYP2C19 P33261 3/20 0.34
ALDH1A1 P00352 2/20 0.34
CYP2D6 P10635 2/20 0.34
ALOX15 P16050 2/20 0.34
HSD17B10 Q99714 2/20 0.34
USP2 O75604 1/20 0.34
TP53 P04637 1/20 0.34
CYP2C9 P11712 1/20 0.34
BLM P54132 1/20 0.34
TDP1 Q9NUW8 8/20 0.33
MAPK1 P28482 6/20 0.33
MAPT P10636 2/20 0.33
HIF1A Q16665 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7569354 0.88 TDP1 (0.35) PTPN1MEN1KMT2ALMNACYP1A2
SCHEMBL12952370 0.88 TDP1 (0.33) MEN1KMT2ALMNACYP1A2CYP3A4
SCHEMBL7525851 0.87 TDP1 (0.32) MEN1KMT2ALMNACYP1A2CYP3A4
SCHEMBL7568918 0.87 ALDH1A1 (0.40) PTPN1MEN1KMT2ALMNACYP1A2
SCHEMBL11983659 0.87 TDP1 (0.36) PTPN1MEN1KMT2ALMNACYP1A2
SCHEMBL12259683 0.85 MEN1 (0.34) MEN1KMT2ALMNACYP1A2CYP3A4
SCHEMBL7566030 0.85 TDP1 (0.31) MEN1KMT2ALMNACYP1A2CYP3A4
SCHEMBL6480424 0.84 SLC2A1 (0.32) MEN1KMT2ALMNACYP2C19ALDH1A1
SCHEMBL18696159 0.84 MEN1 (0.31) MEN1KMT2AKDM1A
SCHEMBL7528138 0.83 MEN1 (0.33) MEN1KMT2ALMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0984929-B1 NAPHTHOPYRAN DERIVATIVES, COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THE SAME CORNING SA (FR) 2002-09-11 EP claimed
EP-2714767-B1 PHOTOCHROMIC POLYMERS VIVIMED LABS EUROPE LTD (GB) 2020-07-22 EP disclosed
US-9250356-B2 Photochromic polymers VIVIMED LABS EUROPE LTD (GB) 2016-02-02 US disclosed
US-9250356-B2 Photochromic polymers VIVIMED LABS EUROPE LTD (GB) 2016-02-02 US disclosed
US-9217812-B2 Photochromic polymer VIVIMED LABS EUROPE LTD (GB) 2015-12-22 US disclosed
US-9217812-B2 Photochromic polymer VIVIMED LABS EUROPE LTD (GB) 2015-12-22 US disclosed
US-20140042377-A1 Photochromic Polymer VIVIMED LABS EUROPE LTD (GB) 2014-02-13 US disclosed
US-20140042377-A1 Photochromic Polymer VIVIMED LABS EUROPE LTD (GB) 2014-02-13 US disclosed
US-20140027684-A1 PHOTOCHROMIC POLYMERS VIVIMED LABS EUROPE LTD (GB) 2014-01-30 US disclosed
US-20140027684-A1 PHOTOCHROMIC POLYMERS VIVIMED LABS EUROPE LTD (GB) 2014-01-30 US disclosed
WO-2012162725-A1 PHOTOCHROMIC POLYMERS ADVANCED POLYMERIK PTY LTD (AU) 2012-12-06 WO disclosed