Ticolubant

Ticolubant

SCHEMBL1230392

O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ticolubant SCHEMBL29370595 1.00 LTB4R (1.00) LTB4R
Ticolubant SCHEMBL1892766 1.00 LTB4R (1.00) LTB4R
SCHEMBL7020052 0.95 LTB4R (1.00) LTB4R
SCHEMBL7020057 0.95 LTB4R (1.00) LTB4R
SCHEMBL7016952 0.94 LTB4R (1.00) LTB4R
SCHEMBL7020389 0.94 LTB4R (1.00) LTB4R
SCHEMBL7021487 0.94 LTB4R (0.94) LTB4R
SCHEMBL7021492 0.94 LTB4R (0.94) LTB4R
SCHEMBL7020038 0.93 LTB4R (1.00) LTB4R
SCHEMBL7020046 0.93 LTB4R (1.00) LTB4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190216790-A1 Methods for Treating Pruritis THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-07-18 US claimed
WO-2018071687-A1 METHODS OF TREATING PRURITIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-04-19 WO claimed
US-20170333516-A1 PREVENTIVE OR THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION JUNTENDO EDUCATIONAL FOUNDATION (JP) 2017-11-23 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
WO-2001034133-A2 ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2001-05-17 WO claimed
WO-2001034134-A2 ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2001-05-17 WO claimed
WO-2001034199-A2 ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2001-05-17 WO claimed
EP-0821673-B1 NEW FORM OF (E)-3- 6- (2,6-DICHLOROPHENYL)-THIO]METHYL]-3-(2-PHENYLETHOXY)-2-PYRIDINYL]-2-PROPENOIC ACID SMITHKLINE BEECHAM PLC (GB) 2001-01-24 EP claimed
US-6093828-A FOR TREATMENT OF PSORIASIS; RESISTANCE TO SUNLIGHT SMITHKLINE BEECHAM P.L.C. (GB) 2000-07-25 US claimed
EP-0821673-A1 NEW FORM OF (E)-3- 6- (2,6-DICHLOROPHENYL)-THIO]METHYL]-3-(2-PHENYLETHOXY)-2-PYRIDINYL]-2-PROPENOIC ACID SMITHKLINE BEECHAM PLC (GB) 1998-02-04 EP claimed
WO-1996033174-A1 NEW FORM OF (E)-3-[6-[[(2,6-DICHLOROPHENYL)-THIO]METHYL]-3-(2-PHENYLETHOXY)-2-PYRIDINYL]-2-PROPENOIC ACID SMITHKLINE BEECHAM PLC (GB) 1996-10-24 WO claimed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 EP disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 US disclosed
WO-1996026725-A1 METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS SMITHKLINE BEECHAM CORPORATION (US) 1996-09-06 WO disclosed
WO-1995015950-A1 COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1995-06-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190216790-A1 Methods for Treating Pruritis ITCH, CYSLTR2, CYSLTR1 LTB4R 8/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 LTB4R 1206/4885
US-20170333516-A1 PREVENTIVE OR THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION LTB4R, LTA4H, LTB4R2 LTB4R 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.