Sugi Predict

Sugi Predict / Compounds / Ampyrimine

Ampyrimine

Ampyrimine

SCHEMBL1230765

Nc1nc(N)c2c(-c3ccccc3)nc(N)nc2n1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DHFR P00374 1/20 0.61
▸ PIK3CG P48736 1/20 0.61
▸ KDM4E B2RXH2 1/20 0.59
▸ JAK2 O60674 1/20 0.59
▸ GMNN O75496 1/20 0.59
▸ ALDH1A1 P00352 1/20 0.59
▸ LMNA P02545 1/20 0.59
▸ TP53 P04637 1/20 0.59
▸ CYP1A2 P05177 1/20 0.59
▸ GLA P06280 1/20 0.59
▸ CTSG P08311 1/20 0.59
▸ CYP3A4 P08684 1/20 0.59
▸ GAA P10253 1/20 0.59
▸ CYP2D6 P10635 1/20 0.59
▸ CYP2C9 P11712 1/20 0.59
▸ PKM P14618 1/20 0.59
▸ HPGD P15428 1/20 0.59
▸ TSHR P16473 1/20 0.59
▸ ALOX12 P18054 1/20 0.59
▸ NFKB1 P19838 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ampyrimine SCHEMBL11050128 0.90 PIK3CG (0.51) DHFRPIK3CGKDM4EJAK2GMNN
Ampyrimine SCHEMBL11283058 0.90 PIK3CG (0.51) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL27721480 0.81 DHFR (0.57) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL16463518 0.79 CSNK1A1 (0.61) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL29380495 0.77 DHFR (0.53) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL2473930 0.76 DHFR (0.58) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL3746280 0.76 PIK3CG (1.00) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL10379276 0.75 DHFR (0.50) DHFRPIK3CGKDM4EJAK2GMNN
SCHEMBL27612323 0.74 CSNK1A1 (0.55) DHFRPIK3CGKDM4EJAK2GMNN
Hydrochloric Acid SCHEMBL15487768 0.74 DHFR (0.56) DHFRPIK3CGKDM4EJAK2GMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
US-4425346-A ANTIGLAUCOMA AGENTS SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) 1984-01-10 — — US claimed
EP-0059524-A1 Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines Smith and Nephew Associated Companies p.l.c. (GB) 1982-09-08 — — EP claimed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 — — EP disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 — — US disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 — — US disclosed
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2023-04-20 — — US disclosed
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels ASCENDIS PHARMA A/S (DE) 2023-01-24 — — US disclosed
EP-4011396-A1 RELEASABLE CONJUGATES QuiaPEG Pharmaceuticals AB (SE) 2022-06-15 — — EP disclosed
WO-2002045693-A1 PHARMACEUTICAL PREPARATION COMPRISING AN ACTIVE DISPERSED ON A MATRIX ALTANA PHARMA AG (DE) 2002-06-13 — — WO disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 — — US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 — — US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 — — US disclosed
US-4425346-A ANTIGLAUCOMA AGENTS SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) 1984-01-10 — — US disclosed
EP-0059524-A1 Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines Smith and Nephew Associated Companies p.l.c. (GB) 1982-09-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 DHFR 1250/4885PIK3CG 871/4885KDM4E 1756/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 DHFR 53/4885PIK3CG 4666/4885KDM4E 3590/4885
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels PLG, PHYKPL, PLOD3 DHFR 1250/4885PIK3CG 871/4885KDM4E 1756/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 DHFR 53/4885PIK3CG 4666/4885KDM4E 3590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.