Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SETDB1 | Q15047 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320186 | 0.85 | KCNA5 (0.40) | SOSTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL16692647 | 0.81 | ALDH1A1 (0.51) | NPSR1DYRK1ACLK4LMNAALDH1A1 | |
| SCHEMBL16692646 | 0.80 | NAMPT (0.46) | NPSR1L3MBTL1LMNAACVR1BTGFBR1 | |
| SCHEMBL14960629 | 0.79 | SOST (0.54) | MTNR1ANPSR1SETDB1CLK1CLK2 | |
| SCHEMBL20959793 | 0.78 | SLC6A2 (0.42) | RPS6KA3 | |
| SCHEMBL10188339 | 0.76 | LMNA (0.41) | L3MBTL1LMNASMN1; SMN2RPS6KA3 | |
| SCHEMBL10061709 | 0.76 | ALDH1A1 (0.45) | MTNR1ANPSR1SETDB1CLK1CLK2 | |
| SCHEMBL12320462 | 0.75 | NAMPT (0.39) | SETDB1CLK2CDK5DYRK1ACLK4 | |
| SCHEMBL19323035 | 0.75 | LMNA (0.43) | MTNR1ANPSR1SETDB1CLK1CLK2 | |
| SCHEMBL30421834 | 0.75 | POLB (0.51) | MTNR1ACLK1CLK2CLK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | MTNR1A 1912/4885NPSR1 3005/4885SETDB1 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.