Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320561 | 0.82 | HPGD (0.68) | ALDH1A1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL12320463 | 0.81 | MTNR1A (0.41) | ALDH1A1KMT2ALMNASMN1; SMN2NPSR1 | |
| SCHEMBL12320186 | 0.79 | KCNA5 (0.40) | ALDH1A1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL12277059 | 0.76 | KDM4D (0.62) | ALDH1A1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL16692646 | 0.75 | NAMPT (0.46) | LMNANPSR1NAMPTKCNA5CYP3A4 | |
| SCHEMBL21104852 | 0.73 | ALDH1A1 (0.38) | ALDH1A1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL6910838 | 0.73 | LMNA (0.55) | ALDH1A1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL20959793 | 0.73 | SLC6A2 (0.42) | EPHX2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1161697 | 0.71 | MMP13 (0.82) | ALDH1A1LMNASMN1; SMN2HTTNAMPT | |
| SCHEMBL1161997 | 0.71 | NAMPT (0.75) | ALDH1A1KMT2ALMNAHTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | ALDH1A1 4256/4885HPGD 2889/4885KMT2A 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.