Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29790993 | 1.00 | APOBEC3G (0.38) | APOBEC3GGABRA1TAAR1GABRG2GABRB3 | |
| SCHEMBL6525315 | 0.86 | APOBEC3G (0.35) | APOBEC3GGABRA1TAAR1GABRG2GABRB3 | |
| SCHEMBL1046232 | 0.85 | GABRA1 (0.42) | GABRA1TAAR1GABRG2GABRB3GABRB2 | |
| SCHEMBL1294030 | 0.85 | GABRA1 (0.46) | APOBEC3GGABRA1TAAR1GABRG2GABRB3 | |
| SCHEMBL27388 | 0.82 | APOBEC3G (0.46) | APOBEC3GGABRA1GABRG2GABRB3HDAC3 | |
| SCHEMBL2729500 | 0.81 | ALDH1A1 (0.43) | APOBEC3GGABRA1TAAR1HDAC3HDAC1 | |
| Benzene SCHEMBL7199484 | 0.79 | PDCD1 (0.46) | APOBEC3GGABRA1GABRG2GABRB3HDAC3 | |
| SCHEMBL10193936 | 0.79 | KDM4E (0.34) | APOBEC3GGABRA1GABRG2GABRB3HDAC3 | |
| SCHEMBL608328 | 0.78 | GABRA1 (0.42) | APOBEC3GGABRA1TAAR1PDCD1CD274 | |
| SCHEMBL6942317 | 0.78 | APOBEC3G (0.39) | APOBEC3GGABRA1TAAR1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317287-B1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-31 | — | — | EP | disclosed |
| EP-3317287-B1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-31 | — | — | EP | disclosed |
| US-10239894-B2 | Inhibitors of indoleamine 2,3-dioxygenase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-26 | — | — | US | disclosed |
| US-10239894-B2 | Inhibitors of indoleamine 2,3-dioxygenase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-26 | — | — | US | disclosed |
| US-20180298035-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-10-18 | — | — | US | disclosed |
| WO-2017002078-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-05 | — | — | WO | disclosed |
| WO-2011022337-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180298035-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, INMT | APOBEC3G 305/4885GABRA1 3162/4885TAAR1 1806/4885 |
| US-10239894-B2 | Inhibitors of indoleamine 2,3-dioxygenase | IDO1, IDO2, INMT | APOBEC3G 305/4885GABRA1 3162/4885TAAR1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.