SCHEMBL1233377

SCHEMBL1233377

CCOC(=O)C(F)(F)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.38
MAPT P10636 3/20 0.36
KMT2A Q03164 2/20 0.36
POLB P06746 2/20 0.36
KDM4E B2RXH2 2/20 0.36
HTT P42858 2/20 0.35
MEN1 O00255 1/20 0.35
CYP4F2 P78329 2/20 0.34
CYP4A11 Q02928 2/20 0.34
PKM P14618 2/20 0.34
THRB P10828 1/20 0.34
LMNA P02545 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HIF1A Q16665 1/20 0.33
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1235041 0.98 TSHR (0.38) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL7931466 0.88 CYP4F2 (0.37) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL7928041 0.83 MAPT (0.36) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL7254521 0.81 CYP4F2 (0.37) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL7255413 0.80 KMT2A (0.41) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL6746280 0.80 THRB (0.32) THRB
SCHEMBL6746654 0.77 MEN1 (0.41) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL9854447 0.77 TRPA1 (0.41) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL9854290 0.77 TRPA1 (0.41) TSHRMAPTKMT2APOLBKDM4E
SCHEMBL197278 0.76 THRB (0.46) TSHRMAPTKMT2APOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2287270-B1 Compound containing a fluorinated amide group DU PONT (US) 2013-04-03 EP disclosed
US-8389657-B2 Poly(meth)acrylamides and poly(meth)acrylates containing flourinated amide E. I. DU PONT DE NEMOURS AND COMPANY (US) 2013-03-05 US disclosed
EP-2251363-B1 Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide DU PONT (US) 2012-12-26 EP disclosed
US-20120264972-A1 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-10-18 US disclosed
EP-2054452-B1 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE DU PONT (US) 2012-09-19 EP disclosed
US-8178638-B2 Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-15 US disclosed
EP-2287270-A2 Composition containing fluorinated amide E. I. du Pont de Nemours and Company (US) 2011-02-23 EP disclosed
EP-2251363-A1 Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide E. I. du Pont de Nemours and Company (US) 2010-11-17 EP disclosed
US-20100233419-A1 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE E.I.DU PONT DE NEMOURS AND COMPANY (US) 2010-09-16 US disclosed
US-7754838-B2 Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-13 US disclosed
EP-2054452-A2 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-05-06 EP disclosed
WO-2008021153-A2 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-02-21 WO disclosed
US-20080039605-A1 Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide E. I. DU PONT DE NEMOURS AND COMPANY 2008-02-14 US disclosed
EP-0822175-B1 Hydrogen-containing fluorosurfactant and its use in polymerisation DU PONT (US) 2001-05-16 EP disclosed
US-5763552-A Hydrogen-containing flourosurfacant and its use in polymerization E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-06-09 US disclosed
EP-0822175-A2 Hydrogen-containing fluorosurfactant and its use in polymerisation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-02-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100233419-A1 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE FGB, AFF1, AFF4 TSHR 1632/4885MAPT 4421/4885KMT2A 1259/4885
US-20120264972-A1 POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE AFF1, AFF2, AFF4 TSHR 536/4885MAPT 4395/4885KMT2A 1002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.