Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | EDNRB | P24530 | 4/20 | 0.48 |
| ▸ | EDNRA | P25101 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350452 | 0.88 | EDNRA (0.54) | KEAP1KMT2AALOX5APFEN1MEN1 | |
| SCHEMBL12336164 | 0.84 | EDNRA (0.51) | KMT2AALOX5APFEN1MEN1EDNRB | |
| SCHEMBL27575420 | 0.83 | KMT2A (0.54) | KEAP1KMT2AALOX5APFEN1MEN1 | |
| SCHEMBL14940241 | 0.80 | KEAP1 (0.62) | KEAP1KMT2AMEN1CA1CA2 | |
| SCHEMBL30737530 | 0.77 | POLB (0.60) | KEAP1KMT2AMEN1EDNRBEDNRA | |
| SCHEMBL3653048 | 0.77 | KEAP1 (0.59) | KEAP1KMT2AMEN1EDNRACA1 | |
| SCHEMBL29118833 | 0.77 | PGR (0.65) | KEAP1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29118847 | 0.77 | ALDH1A1 (0.65) | KEAP1KMT2AMEN1CA1CA2 | |
| SCHEMBL19603196 | 0.76 | KEAP1 (0.58) | KEAP1KMT2AMEN1EDNRACA1 | |
| SCHEMBL3081180 | 0.75 | KEAP1 (1.00) | KEAP1KMT2AMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353538-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2015-12-10 | — | — | US | disclosed |
| WO-2011109441-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353538-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | NFATC1, CD47, CD4 | KEAP1 1375/4885KMT2A 3000/4885ALOX5AP 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.