Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233601 | 0.85 | SLC22A12 (0.59) | SLC22A12ABCB1CA2CALM1KCNH2 | |
| SCHEMBL955065 | 0.83 | SLC22A12 (0.78) | SLC22A12GAAMAPTALDH1A1TSHR | |
| SCHEMBL12493966 | 0.83 | SLC22A12 (0.57) | SLC22A12NPC1RAB9AABCB1CA2 | |
| SCHEMBL1009161 | 0.82 | SLC22A12 (0.53) | SLC22A12NPC1POLBRAB9AMRGPRX4 | |
| SCHEMBL1234546 | 0.82 | SLC22A12 (0.56) | SLC22A12NPC1RAB9AABCB1CA2 | |
| SCHEMBL1007810 | 0.80 | SLC22A12 (0.58) | SLC22A12POLBGAAHSD17B10MAPT | |
| SCHEMBL3239903 | 0.80 | BCHE (0.60) | NPC1POLBRAB9AABCB1BCHE | |
| SCHEMBL31361425 | 0.80 | BCHE (0.60) | NPC1POLBRAB9AABCB1BCHE | |
| SCHEMBL3411267 | 0.78 | RAB9A (0.60) | NPC1POLBRAB9AGAAABCB1 | |
| SCHEMBL12493963 | 0.77 | ALDH1A1 (0.51) | SLC22A12POLBGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282736-B1 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORP (US) | 2015-11-11 | — | — | EP | disclosed |
| US-8889724-B2 | Tetrazole compounds for reducing uric acid | WELLSTAT THERAPEUTICS CORPORATION (US) | 2014-11-18 | — | — | US | disclosed |
| US-20130336949-A1 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2013-12-19 | — | — | US | disclosed |
| US-8410154-B2 | Tetrazole compounds for reducing uric acid | WELLSTAT THERAPEUTICS CORPORATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-20110206653-A1 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2011-08-25 | — | — | US | disclosed |
| EP-2282736-A2 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | Wellstat Therapeutics Corporation (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009134995-A2 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130336949-A1 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | GLS, CASP1, PCSK9 | SLC22A12 637/4885NPC1 1601/4885POLB 4103/4885 |
| US-20110206653-A1 | TETRAZOLE COMPOUNDS FOR REDUCING URIC ACID | FPR1, CASP1, PON1 | SLC22A12 1227/4885NPC1 1222/4885POLB 3781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.