Histidine

Histidine

SCHEMBL123616

N[C@@H](Cc1cnc[nH]1)C(=O)O.[Zn]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 2/20 0.97
▸ SLC7A5 Q01650 1/20 0.97
▸ CPB2 Q96IY4 1/20 0.57
▸ ALDH1A1 P00352 4/20 0.56
▸ HRH4 Q9H3N8 3/20 0.56
▸ HRH3 Q9Y5N1 3/20 0.56
▸ NFKB1 P19838 2/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ GLA P06280 1/20 0.56
▸ KMT2A Q03164 1/20 0.56
▸ CYP1A2 P05177 1/20 0.56
▸ THPO P40225 1/20 0.56
▸ LMNA P02545 1/20 0.54
▸ APEX1 P27695 1/20 0.54
▸ BLM P54132 1/20 0.54
▸ GABRA1 P14867 1/20 0.53
▸ TSHR P16473 1/20 0.53
▸ GABRR1 P24046 1/20 0.53
▸ GABRR2 P28476 1/20 0.53
▸ GABRA5 P31644 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Histidine SCHEMBL28977989 1.00 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL28211929 0.98 CYP3A4 (0.93) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL2782316 0.98 CYP3A4 (0.93) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL388560 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL3260 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL137600 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL28071764 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL30852263 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
D-Histidine SCHEMBL288043 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL19974306 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 396 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116615180-B Hydroxyapatite composition for the treatment and/or prevention of viral infections 库特沃夫博士有限及两合公司 2026-05-12 — — CN claimed
EP-4588522-B1 COMPOSITION FOR TREATMENT AND/OR PREVENTION OF A CORONA VIRUS INFECTION DR KURT WOLFF GMBH & CO KG (DE) 2026-01-21 — — EP claimed
US-20260000707-A1 Tablet with improved stability NOBELPHARMA CO., LTD. (JP) 2026-01-01 — — US claimed
US-20250288653-A1 ARTIFICIAL BLOOD SUBSTITUTES CHANG THOMAS MING SWI (CA) 2025-09-18 — — US claimed
EP-4588522-A2 COMPOSITION FOR TREATMENT AND/OR PREVENTION OF A CORONA VIRUS INFECTION Dr. Kurt Wolff GmbH & Co. KG (DE) 2025-07-23 — — EP claimed
EP-4304738-B1 COMPOSITION FOR TREATMENT AND/OR PREVENTION OF A CORONA VIRUS INFECTION DR KURT WOLFF GMBH & CO KG (DE) 2025-06-18 — — EP claimed
EP-3973966-B1 HYDROXYAPATITE COMPOSITION FOR TREATMENT AND/OR PREVENTION OF A VIRUS INFECTION DR KURT WOLFF GMBH & CO KG (DE) 2025-02-26 — — EP claimed
US-20240148838-A1 Composition for Treatment and/or Prevention of a Corona Virus Infection DR. KURT WOLFF GMBH & CO. KG (DE) 2024-05-09 — — US claimed
EP-3359138-B1 DIETARY SUPPLEMENTATION TO ACHIEVE OXY-REDOX HOMEOSTASIS AND EPIGENETIC STABILITY PARTHENOGEN SAGL (CH) 2024-04-24 — — EP claimed
EP-4056234-B1 COMPOSITION FOR TREATMENT AND/OR PREVENTION OF A CORONA VIRUS INFECTION DR KURT WOLFF GMBH & CO KG (DE) 2024-04-17 — — EP claimed
EP-1663141-B1 AQUEOUS PHARMACEUTICAL SOLUTION CONTAINING OXYMETAZOLINE AND/OR XYLOMETAZOLINE MERCK PATENT GMBH (DE) 2007-03-21 — — EP claimed
US-20060222718-A1 Aqueous pharmaceutical solution comprising oxymetazoline and/or xylometazoline MERCK PATENT GMBH (DE) 2006-10-05 — — US claimed
CN-1832726-A Aqueous pharmaceutical solution containing oxymetazoline and/or xylometazoline MERCK PATENT GMBH (DE) 2006-09-13 — — CN claimed
WO-2006083980-A1 AN EMULSION COMPOSITION FOR WET WIPES CONTAINING A NON-IRRITATING SKIN HEALTH BENEFIT INGREDIENT AND THE PROCESS FOR MAKING SAID WET-WIPES THE PROCTER & GAMBLE COMPANY (US) 2006-08-10 — — WO claimed
US-20060171971-A1 Composition for wet wipes containing a non-irritating skin health benefit ingredient and the process for making THE PROCTER & GAMBLE COMPANY 2006-08-03 — — US claimed
US-20040105894-A1 Trace Metals synergized copper nucleotides and copper glycosides for anti-aging and antiviral compositions GUPTA SHYAM K (US) 2004-06-03 — — US claimed
EP-0245669-B1 Pharmaceutical preparation for preventing damage to living cells by free radicals, or for increasing the efficacy of organic sulphur compounds, and process for increasing the life span of isolated organs FLOERSHEIM GEORG L (CH) 1993-12-01 — — EP claimed
US-5234698-A Increases amount of prostatic antibacterial factor FAHIM MOSTAFA S (US) 1993-08-10 — — US claimed
US-5071658-A Increase antibacterial factor and inhibits growth; antiandrogen agent FAHIM MOSTAFA S (US) 1991-12-10 — — US claimed
US-4946688-A ANTIGROWTH AGENTS FAHIM MOSTAFA S (US) 1990-08-07 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260000707-A1 Tablet with improved stability GYS2, SORD, TREH CYP3A4 2663/4885SLC7A5 257/4885CPB2 1414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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