Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10752401 | 0.98 | OPRM1 (0.50) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL24422207 | 0.90 | OPRM1 (0.59) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL20003963 | 0.89 | OPRM1 (0.62) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL19462825 | 0.84 | OPRM1 (0.43) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL18115648 | 0.83 | ALDH1A1 (0.58) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL28301582 | 0.82 | OPRM1 (0.49) | OPRM1GRIN1GRIN2AGRIN2BHSD11B1 | |
| SCHEMBL2629517 | 0.81 | OPRM1 (0.70) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL23773726 | 0.79 | OPRM1 (0.53) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL16510074 | 0.78 | OPRM1 (0.53) | OPRM1GRIN1GRIN2AHSD11B1OPRL1 | |
| SCHEMBL3025606 | 0.77 | OPRM1 (0.56) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247401-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20110206783-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME LLC | 2011-08-25 | — | — | US | disclosed |
| US-20100266714-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME LLC | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100266714-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | P2RX3, P2RX1, P2RX2 | OPRM1 40/4885GRIN2D 1036/4885GRIN3B 108/4885 |
| US-20110206783-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | P2RX3, P2RX1, P2RX2 | OPRM1 43/4885GRIN2D 1117/4885GRIN3B 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.