Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24422207 | 0.85 | OPRM1 (0.59) | ALDH1A1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL12363963 | 0.83 | OPRM1 (0.51) | ALDH1A1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL2629517 | 0.82 | OPRM1 (0.70) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL10752401 | 0.81 | OPRM1 (0.50) | ALDH1A1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL15543215 | 0.81 | OPRM1 (0.43) | ALDH1A1OPRM1CHRM1KCNH2OPRL1 | |
| SCHEMBL23748779 | 0.79 | CCR1 (0.42) | ALDH1A1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL23748773 | 0.78 | OPRM1 (0.37) | ALDH1A1OPRM1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL24421814 | 0.78 | ALDH1A1 (0.37) | ALDH1A1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL569815 | 0.78 | ALDH1A1 (0.37) | ALDH1A1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL9966015 | 0.77 | OPRM1 (0.48) | ALDH1A1OPRM1GRIN2BOPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144838-A1 | Compounds as Inhibitors of Macrophage Migration Inhibitory Factor | Nanjing Immunophage Biotech Co., Ltd. (CN) | 2022-05-12 | — | — | US | disclosed |
| EP-3277677-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2018-02-07 | — | — | EP | disclosed |
| WO-2016156816-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2016-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144838-A1 | Compounds as Inhibitors of Macrophage Migration Inhibitory Factor | MIF, MMP12, SLC11A2 | ALDH1A1 2121/4885OPRM1 2541/4885GRIN2D 3746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.