Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365403 | 0.85 | AR (0.49) | CYP3A4CYP11B2CYP17A1ALDH1A1SRD5A2 | |
| SCHEMBL12365082 | 0.84 | ESR2 (0.46) | CYP3A4CYP11B2CYP17A1ALDH1A1SRD5A2 | |
| SCHEMBL12365128 | 0.84 | CYP11B2 (0.45) | CYP3A4CYP11B2CYP17A1CYP11B1MAPK14 | |
| SCHEMBL12365051 | 0.84 | KMO (0.51) | CYP11B2CYP17A1CYP11B1ALDH1A1SRD5A2 | |
| SCHEMBL12364987 | 0.83 | RARB (0.48) | ALDH1A1SRD5A2SRD5A1IP6K1IP6K3 | |
| SCHEMBL12364994 | 0.83 | SRD5A2 (0.49) | ALDH1A1SRD5A2SRD5A1TDP2 | |
| SCHEMBL12365038 | 0.83 | MAPT (0.41) | ALDH1A1SRD5A2SRD5A1TDP2MAPT | |
| SCHEMBL12365813 | 0.83 | KDM4C (0.37) | CYP3A4CYP11B2CYP17A1ALDH1A1SRD5A2 | |
| SCHEMBL12365885 | 0.83 | SRD5A2 (0.38) | CYP3A4CYP11B2CYP17A1CYP11B1ALDH1A1 | |
| SCHEMBL12390197 | 0.83 | RARA (0.49) | SRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| EP-2177505-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | CYP3A4 1108/4885CYP11B2 707/4885CYP17A1 1053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.