Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2259471 | 0.89 | MEN1 (0.38) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12365061 | 0.88 | CYP4F2 (0.45) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12389043 | 0.88 | AOC3 (0.43) | RAB9AHTR7CHUKINSRMAPK8 | |
| SCHEMBL12366703 | 0.83 | HTR2B (0.40) | HTR7F2F10PRSS1CHUK | |
| SCHEMBL12364980 | 0.82 | MAPK14 (0.42) | ALDH1A1MAPTRAB9ALOXL2CYP4F2 | |
| SCHEMBL12365070 | 0.82 | RARA (0.41) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2259460 | 0.82 | PTGS2 (0.47) | MAPTRAB9AMEN1KMT2ATSHR | |
| SCHEMBL12364999 | 0.81 | SLC6A3 (0.47) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL12365033 | 0.81 | HSD17B3 (0.41) | RAB9ALOXL2CYP4F2CYP4A11ROCK2 | |
| SCHEMBL12364998 | 0.81 | MAPK14 (0.44) | ALDH1A1MAPTRAB9ASMN1; SMN2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | KDM4E 1455/4885ALDH1A1 934/4885MAPT 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.