Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366134 | 0.87 | KMO (0.49) | SLC2A1ALDH1A1MKNK1MKNK2ABL1 | |
| SCHEMBL12366158 | 0.86 | CYP46A1 (0.40) | CYP19A1CYP11B1CYP11B2ALDH1A1NEK1 | |
| SCHEMBL12365206 | 0.86 | PTGS2 (0.46) | SMN1; SMN2NPC1RAB9AGABRA5MAPT | |
| SCHEMBL12366593 | 0.82 | MKNK1 (0.42) | MKNK1MKNK2 | |
| SCHEMBL12366160 | 0.81 | ABL1 (0.41) | CYP19A1CYP11B1CYP11B2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12366260 | 0.81 | CYP1A2 (0.37) | ALDH1A1SMN1; SMN2NPC1RAB9AROCK2 | |
| SCHEMBL12365858 | 0.79 | PTGS1 (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AGABRA5 | |
| SCHEMBL12389750 | 0.79 | ALOX15 (0.43) | CYP19A1CYP11B1CYP11B2SLC2A1ALDH1A1 | |
| SCHEMBL12366157 | 0.79 | ALOX15 (0.43) | CYP19A1CYP11B1CYP11B2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12366126 | 0.79 | ALOX15 (0.45) | CYP19A1CYP11B1CYP11B2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | CYP19A1 978/4885CYP11B1 662/4885CYP11B2 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.