Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366117 | 0.84 | HDAC1 (0.56) | EPHX2HDAC3HDAC8HDAC6RAB9A | |
| SCHEMBL19513354 | 0.82 | EPHX2 (0.62) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL12366188 | 0.82 | LMNA (0.47) | KMT2ALMNAALDH1A1 | |
| SCHEMBL12366100 | 0.82 | ALDH1A1 (0.56) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL12993441 | 0.80 | EPHX2 (0.59) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL5178356 | 0.80 | EPHX2 (0.64) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL3421393 | 0.79 | MEN1 (0.60) | EPHX2NR1H4HDAC3HDAC8HDAC6 | |
| SCHEMBL12366096 | 0.79 | L3MBTL1 (0.57) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL12366142 | 0.79 | KMT2A (0.59) | MEN1KMT2ACYP2C19RAB9AALDH1A1 | |
| SCHEMBL249685 | 0.79 | EPHX2 (0.62) | EPHX2NR1H4HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |