Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366192 | 0.84 | EPHX2 (0.54) | HDAC8HDAC3HDAC6NPC1RAB9A | |
| SCHEMBL12366113 | 0.82 | L3MBTL1 (0.63) | NPC1RAB9AMAPK14LMNAPOLB | |
| SCHEMBL12366135 | 0.82 | LMNA (0.62) | CA12CA1CA2NPC1RAB9A | |
| SCHEMBL12366146 | 0.81 | EPHX2 (0.53) | CA12CA1CA2CA7NAMPT | |
| SCHEMBL12366188 | 0.79 | LMNA (0.47) | CA12CA1CA2CA7LMNA | |
| SCHEMBL12366096 | 0.79 | L3MBTL1 (0.57) | CA12CA1CA2CA7POLB | |
| SCHEMBL10594986 | 0.79 | HDAC3 (0.60) | HDAC1HDAC8HDAC3HDAC2HDAC10 | |
| SCHEMBL6366481 | 0.79 | ALDH1A1 (0.57) | RAB9ALMNAALDH1A1 | |
| SCHEMBL934145 | 0.79 | HDAC3 (0.60) | HDAC1HDAC8HDAC3HDAC2HDAC10 | |
| SCHEMBL12366142 | 0.79 | KMT2A (0.59) | CA12CA1CA2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |