Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366188 | 0.86 | LMNA (0.47) | ALDH1A1TDP1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL12366142 | 0.83 | KMT2A (0.59) | ALDH1A1TDP1KMT2AMEN1NPC1 | |
| SCHEMBL12366135 | 0.83 | LMNA (0.62) | ALDH1A1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL12366096 | 0.83 | L3MBTL1 (0.57) | ALDH1A1TDP1KMT2AMEN1HPGD | |
| SCHEMBL11591975 | 0.82 | GAA (0.59) | ALDH1A1KMT2AMEN1RAB9ALMNA | |
| SCHEMBL12366176 | 0.82 | NR1H4 (0.46) | ALDH1A1TDP1KMT2AMEN1NPC1 | |
| SCHEMBL12366192 | 0.82 | EPHX2 (0.54) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL12366190 | 0.82 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL12366093 | 0.81 | MMP13 (0.52) | ALDH1A1TDP1NPC1RAB9ALMNA | |
| SCHEMBL12366121 | 0.80 | LMNA (0.64) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |