Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10711290 | 0.98 | NCF1 (0.59) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL4960474 | 0.90 | KDM4E (0.52) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL5722525 | 0.86 | NCF1 (0.58) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL8361520 | 0.85 | DRD2 (0.72) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL18756992 | 0.83 | HTR1A (0.53) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL721985 | 0.82 | NCF1 (0.49) | NCF1MAPK1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29505669 | 0.81 | NCF1 (0.87) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL110927 | 0.81 | NCF1 (0.87) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL14355759 | 0.81 | NCF1 (0.61) | NCF1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL5161795 | 0.81 | NCF1 (0.61) | NCF1DRD2DRD3HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345711-B2 | 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-ones | Impact Therapeutics (Shanghai), Inc (CN) | 2022-05-31 | — | — | US | disclosed |
| US-20200385394-A1 | 8,9-DIHYDROIMIDAZO[1,2-a]PYRIMIDO[5,4-e]PYRIMIDIN-5(6H)-ONES | Impact Therapeutics (Shanghai), Inc (CN) | 2020-12-10 | — | — | US | disclosed |
| US-10703759-B2 | 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-ones | IMPACT THERAPEUTICS, INC (CN) | 2020-07-07 | — | — | US | disclosed |
| US-20190308984-A1 | 8,9-DIHYDROIMIDAZO[1,2-a]PYRIMIDO[5,4-e]PYRIMIDIN-5(6H)-ONES | Impact Therapeutics (Shanghai), Inc (CN) | 2019-10-10 | — | — | US | disclosed |
| US-9442399-B2 | Electrophotographic photosensitive member, process cartridge, electrophotographic apparatus and phthalocyanine crystal | CANON KABUSHIKI KAISHA (JP) | 2016-09-13 | — | — | US | disclosed |
| US-9442399-B2 | Electrophotographic photosensitive member, process cartridge, electrophotographic apparatus and phthalocyanine crystal | CANON KABUSHIKI KAISHA (JP) | 2016-09-13 | — | — | US | disclosed |
| EP-2743772-B1 | Electrophotographic photosensitive member, process cartridge, electrophotographic apparatus and phthalocyanine crystal | CANON KK (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20140170542-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS AND PHTHALOCYANINE CRYSTAL | CANON KABUSHIKI KAISHA (JP) | 2014-06-19 | — | — | US | disclosed |
| US-20140170542-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS AND PHTHALOCYANINE CRYSTAL | CANON KABUSHIKI KAISHA (JP) | 2014-06-19 | — | — | US | disclosed |
| EP-2743772-A1 | Electrophotographic photosensitive member, process cartridge, electrophotographic apparatus and phthalocyanine crystal | Canon Kabushiki Kaisha (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-8530465-B2 | 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2013-09-10 | — | — | US | disclosed |
| US-20130059862-A1 | Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof | HUANG HSU-SHAN (TW) | 2013-03-07 | — | — | US | disclosed |
| US-8304415-B2 | 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2012-11-06 | — | — | US | disclosed |
| US-20110207739-A1 | Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2011-08-25 | — | — | US | disclosed |
| US-7291619-B2 | Melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190308984-A1 | 8,9-DIHYDROIMIDAZO[1,2-a]PYRIMIDO[5,4-e]PYRIMIDIN-5(6H)-ONES | WEE1, WEE2, CCNE1 | NCF1 3087/4885DRD2 4463/4885DRD3 4251/4885 |
| US-11345711-B2 | 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-ones | WEE1, WEE2, CCNE1 | NCF1 3087/4885DRD2 4463/4885DRD3 4251/4885 |
| US-10703759-B2 | 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-ones | WEE1, WEE2, CCNE1 | NCF1 3087/4885DRD2 4463/4885DRD3 4251/4885 |
| US-20110207739-A1 | Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof | ANXA1, ANXA5, ANXA2 | NCF1 1357/4885DRD2 4174/4885DRD3 3905/4885 |
| US-20130059862-A1 | Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof | ANXA5, ANXA1, HCCS | NCF1 1351/4885DRD2 4132/4885DRD3 3867/4885 |
| US-20200385394-A1 | 8,9-DIHYDROIMIDAZO[1,2-a]PYRIMIDO[5,4-e]PYRIMIDIN-5(6H)-ONES | WEE1, WEE2, CCNE1 | NCF1 3087/4885DRD2 4463/4885DRD3 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.