SCHEMBL1237402

SCHEMBL1237402

O=[N+]([O-])/C(Cl)=C/c1cc(Cl)cc(Cl)c1

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 11/20 0.69
TSHR P16473 2/20 0.38
ALDH1A1 P00352 2/20 0.38
TERT O14746 1/20 0.33
TTR P02766 1/20 0.33
AHR P35869 1/20 0.33
ABL1 P00519 1/20 0.33
EGFR P00533 1/20 0.33
ABL2 P42684 1/20 0.33
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1237403 1.00 FBP1 (0.69) FBP1TSHRALDH1A1TERTTTR
SCHEMBL630963 0.82 FBP1 (1.00) FBP1ALDH1A1KDM4EPOLB
SCHEMBL30295762 0.82 FBP1 (1.00) FBP1ALDH1A1KDM4EPOLB
SCHEMBL630964 0.82 FBP1 (1.00) FBP1ALDH1A1KDM4EPOLB
SCHEMBL525207 0.82 FBP1 (1.00) FBP1ALDH1A1KDM4EPOLB
SCHEMBL1235881 0.74 FBP1 (0.51) FBP1
SCHEMBL1235882 0.74 FBP1 (0.51) FBP1
SCHEMBL632451 0.73 FBP1 (1.00) FBP1TSHRALDH1A1
SCHEMBL632452 0.73 FBP1 (1.00) FBP1TSHRALDH1A1
SCHEMBL632453 0.73 FBP1 (1.00) FBP1TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8476309-B2 Benzofuran cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-07-02 US disclosed
US-8476309-B2 Benzofuran cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-07-02 US disclosed
US-8431595-B2 Furanopyridine cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-04-30 US disclosed
US-8431595-B2 Furanopyridine cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-04-30 US disclosed
US-8431595-B2 Furanopyridine cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-04-30 US disclosed
US-20110046175-A1 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046176-A1 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046176-A1 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046175-A1 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046163-A1 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046163-A1 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
WO-2011022692-A2 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed
WO-2011022692-A2 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed
WO-2011022694-A2 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed
WO-2011022694-A2 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed
WO-2011022679-A2 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046176-A1 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE CNR1, CNR2, FAAH FBP1 481/4885TSHR 1591/4885ALDH1A1 1175/4885
US-20110046175-A1 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE CNR1, CNR2, GPR18 FBP1 561/4885TSHR 2189/4885ALDH1A1 576/4885
US-20110046163-A1 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE CNR1, CNR2, GPR17 FBP1 306/4885TSHR 1874/4885ALDH1A1 1206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.