Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16480388 | 0.85 | HSD17B10 (0.41) | TSHRHBBHSD17B10L3MBTL1APLNR | |
| SCHEMBL11474043 | 0.85 | APLNR (0.43) | HSD17B10APLNRKMT2AALDH1A1GAA | |
| SCHEMBL3028744 | 0.82 | ALDH1A1 (0.44) | TSHRHBBHSD17B10L3MBTL1APLNR | |
| SCHEMBL1237860 | 0.81 | APLNR (0.58) | TSHRAPLNRALDH1A1MAPTCA12 | |
| SCHEMBL29175430 | 0.81 | APLNR (0.41) | TSHRHBBHSD17B10L3MBTL1APLNR | |
| SCHEMBL11825770 | 0.81 | ALDH1A1 (0.38) | HSD17B10KMT2AALDH1A1GAAPOLB | |
| SCHEMBL1488919 | 0.80 | NPC1 (0.43) | HSD17B10L3MBTL1APLNRMAOBKMT2A | |
| SCHEMBL13763197 | 0.80 | ALDH1A1 (0.47) | APLNRKMT2AALDH1A1GAAMEN1 | |
| SCHEMBL3992460 | 0.80 | KDM1A (0.42) | APLNRMAOAKDM1AMAOBALDH1A1 | |
| SCHEMBL837958 | 0.80 | SLC6A4 (0.47) | APLNRKMT2AALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2521452-B1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| EP-2521452-B1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| US-8895568-B2 | Compositions comprising substituted pteridines as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-11-25 | — | — | US | disclosed |
| CN-103922965-A | Synthesis method for 4-methoxy-2-methyl benzyl cyanide | XI AN RUILIAN MODERN ELECTRONIC CHEMICALS CO LTD | 2014-07-16 | — | — | CN | disclosed |
| US-20060122392-A1 | Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient | ONO PHARMACEUTICAL CO., LTD. | 2006-06-08 | — | — | US | disclosed |
| WO-2006044958-A1 | PYRAZOLO [1,5-ALPHA] PYRIMIDINYL DERIVATIVES USEFUL AS CORTICOTROPIN-RELEASING FACTOR (CRF) RECEPTOR ANTAGONISTS | SB PHARMCO PUERTO RICO INC. (PR) | 2006-04-27 | — | — | WO | disclosed |
| US-7034153-B2 | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-04-25 | — | — | US | disclosed |
| US-20050143380-A1 | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2005-06-30 | — | — | US | disclosed |
| WO-2005051394-A1 | SALT AND CRYSTALLINE FORM THEREOF OF A CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONIST | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
| WO-2005051954-A2 | PROCESSES FOR THE PREPARATION OF PYRAZOLO[1,5-a]-1,3,5-TRIAZINES AND INTERMEDIATES THEREOF | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
| US-20050113375-A1 | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2005-05-26 | — | — | US | disclosed |
| US-20040072833-A1 | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-04-15 | — | — | US | disclosed |
| EP-1354884-A1 | TRICYCLIC AND HETEROCYCLIC DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002072101-A1 | A CORTICOTROPIN RELEASING FACTOR RECEPTOR LIGAND, ITS ENANTIOMER AND PHARMACEUTICALLY ACCEPTABLE SALTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122392-A1 | Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient | NR3C1, CRHR2, CRHR1 | TSHR 271/4885HBB 1897/4885HSD17B10 1826/4885 |
| US-20050113375-A1 | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist | CRH, CRHR1, CRHR2 | TSHR 200/4885HBB 3544/4885HSD17B10 3160/4885 |
| US-20040072833-A1 | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient | CRH, CRHR1, CRHR2 | TSHR 182/4885HBB 1110/4885HSD17B10 2472/4885 |
| US-20050143380-A1 | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof | CRHR1, CRH, CRHR2 | TSHR 54/4885HBB 3514/4885HSD17B10 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.