Homarylamine

Homarylamine

SCHEMBL1237889

CNCCc1ccc2c(c1)OCO2

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.61
SLC6A2 P23975 2/20 0.57
SLC6A4 P31645 2/20 0.57
SLC6A3 Q01959 2/20 0.57
CYP2D6 P10635 1/20 0.57
KDM4E B2RXH2 2/20 0.56
ALDH1A1 P00352 1/20 0.56
LMNA P02545 1/20 0.56
PKM P14618 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
POLB P06746 1/20 0.55
CALM1 P0DP23 1/20 0.53
TSHR P16473 1/20 0.52
MAPK1 P28482 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Homarylamine SCHEMBL29412731 1.00 TAAR1 (0.61) TAAR1SLC6A2SLC6A4SLC6A3CYP2D6
SCHEMBL2471267 0.90 TAAR1 (0.57) TAAR1SLC6A2SLC6A4SLC6A3CYP2D6
SCHEMBL9608844 0.89 LMNA (0.52) TAAR1KDM4EALDH1A1LMNAPOLB
SCHEMBL27650175 0.88 HDAC1 (0.56) TAAR1SLC6A2SLC6A4SLC6A3CYP2D6
SCHEMBL30928242 0.88 HDAC1 (0.56) TAAR1SLC6A2SLC6A4SLC6A3CYP2D6
SCHEMBL30496700 0.85 POLB (0.66) TAAR1KDM4EALDH1A1LMNAPKM
SCHEMBL9736670 0.83 POLB (0.59) TAAR1KDM4EALDH1A1LMNAPKM
SCHEMBL108087 0.82 TAAR1 (0.77) TAAR1SLC6A2SLC6A4SLC6A3CYP2D6
SCHEMBL14205398 0.82 TAAR1 (0.61) TAAR1SLC6A4KDM4EALDH1A1LMNA
SCHEMBL29261883 0.82 TAAR1 (0.61) TAAR1CYP2D6KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-12043605-B2 Deuterated empathogens ALEXANDER SHULGIN RESEARCH INSTITUTE, INC. (US) 2024-07-23 US disclosed
CN-117956991-A N, N-dimethyltryptamine and related hallucinogens and uses thereof 人类生物科学股份有限公司 2024-04-30 CN disclosed
WO-2023115002-A1 ANALOGS OF 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE TERRAN BIOSCIENCES INC. (US) 2023-06-22 WO disclosed
WO-2023081899-A1 ISOTOPICALLY ENRICHED N-METHYL-1,3-BENZODIOXOLYLBUTANAMINE (MBDB) AND STEREOISOMERS THEREOF TERRAN BIOSCIENCES, INC. (US) 2023-05-11 WO disclosed
US-20230041761-A1 SMALL MOLECULE MODULATORS OF SIGMA-1 AND SIGMA-2 RECEPTORS AND USES THEREOF NORTHWESTERN UNIVERSITY 2023-02-09 US disclosed
WO-2023283373-A1 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND RELATED PSYCHEDLICS AND USES THEREOF TERRAN BIOSCIENCES INC. (US) 2023-01-12 WO disclosed
US-11383084-B2 Treatment of dermatological conditions via neuromodulation PALO ALTO INVESTORS (US) 2022-07-12 US disclosed
US-5120759-A TETRAHYDRONAPHTHALENE DERIVATIVES FOR IMPROVING SHORT-TERM MEMORY HOFFMANN-LA ROCHE INC. (US) 1992-06-09 US disclosed
EP-0065229-B1 BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS Dr. Karl Thomae GmbH (DE) 1985-08-07 EP disclosed
EP-0065229-A1 Benzazepines, process for their preparation and their application as pharmaceutical preparations Dr. Karl Thomae GmbH (DE) 1982-11-24 EP disclosed
US-4134980-A Phenylalkylamino-alkyl derivatives of quinazolinone and phthalazinone BOEHRINGER INGELHEIM GMBH (DE) 1979-01-16 US disclosed
US-4087541-A REDUCING HEART RATE BOEHRINGER INGELHEIM GMBH (DT) 1978-05-02 US disclosed
US-4058607-A DIHALOVINYL DIALKYL PHOSPHATE, 1,3-BENZODIOXOLES AIRWICK INDUSTRIES, INC. (US) 1977-11-15 US disclosed
US-4038407-A HEART RATE SLOWING DRUGS BOEHRINGER INGELHEIM GMBH (DT) 1977-07-26 US disclosed
US-3962415-A Insecticide evaporator comprising DDVP with synergized benzodioxole compound as stabilizer AIRWICK INDUSTRIES, INC. (US) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12043605-B2 Deuterated empathogens SLC18A2, SLC6A3, GAP43 TAAR1 59/4885SLC6A2 5/4885SLC6A4 10/4885
US-20230041761-A1 SMALL MOLECULE MODULATORS OF SIGMA-1 AND SIGMA-2 RECEPTORS AND USES THEREOF SIGMAR1, TMEM97, OPRM1 TAAR1 32/4885SLC6A2 322/4885SLC6A4 580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.