Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 14/20 | 0.69 |
| ▸ | MAPT | P10636 | 13/20 | 0.69 |
| ▸ | SNCA | P37840 | 11/20 | 0.69 |
| ▸ | METAP1 | P53582 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1454822 | 1.00 | APP (0.69) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL31022832 | 0.88 | MAPT (0.57) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL34474369 | 0.83 | MIF (0.65) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL13104436 | 0.81 | CMA1 (0.63) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL28404789 | 0.81 | CMA1 (0.63) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL1454792 | 0.80 | MIF (0.70) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL29609334 | 0.80 | MIF (0.70) | APPMAPTSNCAMETAP1MEN1 | |
| Dimethylamine SCHEMBL5741201 | 0.79 | CMA1 (0.56) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL813820 | 0.77 | MAOB (0.71) | APPMAPTSNCAMETAP1MEN1 | |
| SCHEMBL5356129 | 0.77 | MAOB (0.71) | APPMAPTSNCAMETAP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190492-A1 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE | TOHOKU UNIVERSITY (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20110190492-A1 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE | TOHOKU UNIVERSITY (JP) | 2011-08-04 | — | — | US | disclosed |
| US-7910579-B2 | Benzoxazole derivatives | TOHOKU UNIVERSITY (JP) | 2011-03-22 | — | — | US | disclosed |
| US-20100021385-A1 | BENZOXAZOLE DERIVATIVES | TOHOKU UNIVERSITY (JP) | 2010-01-28 | — | — | US | disclosed |
| US-20090185975-A1 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE | TOHOKU UNIVERSITY (JP) | 2009-07-23 | — | — | US | disclosed |
| US-20090185975-A1 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE | TOHOKU UNIVERSITY (JP) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090185975-A1 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE | TARDBP, LMNA, PMP22 | APP 12/4885MAPT 213/4885SNCA 138/4885 |
| US-20100021385-A1 | BENZOXAZOLE DERIVATIVES | CBX7, KIT, BMX | APP 2668/4885MAPT 1385/4885SNCA 3155/4885 |
| US-20110190492-A1 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE | TARDBP, LMNA, PMP22 | APP 12/4885MAPT 213/4885SNCA 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.