Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.77 |
| ▸ | HTT | P42858 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | TP53 | P04637 | 3/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.69 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | BRAF | P15056 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | MPI | P34949 | 1/20 | 0.65 |
| ▸ | P4HB | P07237 | 2/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30253905 | 0.90 | ALOX12 (0.77) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL11955274 | 0.90 | ALOX12 (0.77) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL1239504 | 0.89 | BRAF (0.75) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL25078986 | 0.87 | ALOX12 (0.77) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL30253589 | 0.87 | ALOX12 (0.77) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL15781874 | 0.87 | ALDH1A1 (1.00) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL30254216 | 0.86 | BRAF (0.63) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL25079471 | 0.86 | BRAF (0.63) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL11896461 | 0.86 | ALOX12 (0.78) | ALDH1A1ALOX12HTTKMT2ATP53 | |
| SCHEMBL1239639 | 0.84 | BRAF (0.76) | ALDH1A1ALOX12HTTKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196853-A1 | Novel Quinoline-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-02 | — | — | US | disclosed |
| US-20120196853-A1 | Novel Quinoline-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-02 | — | — | US | disclosed |
| US-20120196853-A1 | Novel Quinoline-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-02 | — | — | US | disclosed |
| EP-2467361-A1 | NOVEL QUINOLINE-HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011020886-A1 | NOVEL QUINOLINE-HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196853-A1 | Novel Quinoline-Hepcidine Antagonists | HAMP, SLC40A1, FTH1 | ALDH1A1 2250/4885ALOX12 251/4885HTT 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.