SCHEMBL12398554

SCHEMBL12398554

C=COC(=O)OCCCC[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP3A4 P08684 1/20 0.35
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL47743 0.99 TSHR (0.34) TSHRALDH1A1CYP3A4HPGD
SCHEMBL16088296 0.99 TSHR (0.34) TSHRALDH1A1CYP3A4HPGD
SCHEMBL2608074 0.96 TSHR (0.34) TSHRALDH1A1CYP3A4HPGD
SCHEMBL14513850 0.94 TSHR (0.37) TSHRALDH1A1CYP3A4HPGD
SCHEMBL15355894 0.93 TSHR (0.33) TSHRALDH1A1CYP3A4HPGD
SCHEMBL15355895 0.91 ALDH1A1 (0.32) TSHRALDH1A1CYP3A4
SCHEMBL13789040 0.90 ALDH1A1 (0.31) TSHRALDH1A1CYP3A4
SCHEMBL35484 0.90 TSHR (0.36) TSHRALDH1A1CYP3A4HPGD
SCHEMBL12585804 0.89 ALDH1A1 (0.30) TSHRALDH1A1CYP3A4
SCHEMBL12891632 0.89 ALDH1A1 (0.30) TSHRALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180210231-A1 Ophthalmic Apparatus with a Passive Event-Based Coloration System JOHNSON & JOHNSON VISION CARE (US) 2018-07-26 US disclosed
US-9977258-B2 Methods and apparatus to enhance oxygen concentrations for ophthalmic devices JOHNSON & JOHNSON VISION CARE, INC. (US) 2018-05-22 US disclosed
US-9964780-B2 Methods and apparatus to enhance oxygen concentrations for advanced ophthalmic devices JOHNSON & JOHNSON VISION CARE, INC. (US) 2018-05-08 US disclosed
US-9958704-B2 Methods and apparatus for ophthalmic devices including cycloidally oriented liquid crystal layers JOHNSON & JOHNSON VISION CARE, INC. (US) 2018-05-01 US disclosed
US-20180115017-A1 BIOMEDICAL ENERGIZATION ELEMENTS WITH POLYMER ELECTROLYTES JOHNSON & JOHNSON VISION CARE, INC. 2018-04-26 US disclosed
US-9923177-B2 Biocompatibility of biomedical energization elements JOHNSON & JOHNSON VISION CARE, INC. (US) 2018-03-20 US disclosed
US-20180076465-A1 TUBULAR FORM BIOMEDICAL DEVICE BATTERIES WITH ELECTROLESS SEALING JOHNSON & JOHNSON VISION CARE, INC. 2018-03-15 US disclosed
US-9869885-B2 Method and apparatus for ophthalmic devices including gradient-indexed liquid crystal layers and shaped dielectric layers JOHNSON & JOHNSON VISION CARE, INC. (US) 2018-01-16 US disclosed
US-9823492-B2 Methods and apparatus for ophthalmic devices including cycloidally oriented liquid crystal layers JOHNSON & JOHNSON VISION CARE, INC. (US) 2017-11-21 US disclosed
US-20170312947-A1 METHOD OF MANUFACTURING HYDROGEL OPHTHALMIC DEVICES WITH ELECTRONIC ELEMENTS JOHNSON & JOHNSON VISION CARE (US) 2017-11-02 US disclosed
US-20090244477-A1 OPHTHALMIC LENS MEDIA INSERT JOHNSON & JOHNSON VISION CARE, INC. 2009-10-01 US disclosed
US-20090243125-A1 METHODS AND APPARATUS FOR INK JET PROVIDED ENERGY RECEPTOR JOHNSON & JOHNSON VISION CARE, INC. 2009-10-01 US disclosed
US-20090244479-A1 TINTED SILICONE OPHTHALMIC DEVICES, PROCESSES AND POLYMERS USED IN THE PREPARATION OF SAME JOHNSON & JOHNSON VISION CARE, INC. 2009-10-01 US disclosed
US-20090206498-A1 ENERGIZED BIOMEDICAL DEVICE JOHNSON & JOHNSON VISION CARE, INC. 2009-08-20 US disclosed
US-20090168014-A1 LASER ENHANCED LENS JOHNSON & JOHNSON VISION CARE, INC. 2009-07-02 US disclosed
US-20080273168-A1 ANTIMICROBIAL LENSES, PROCESSES TO PREPARE THEM AND METHODS OF THEIR USE JOHNSON & JOHNSON VISION CARE, INC. 2008-11-06 US disclosed
US-20080114123-A1 Anionic polymers having sulfonate, sulfate, phosphonate, phosphate or borate grouops capable of acting as osmotic drivers for contact lenses and medical equipment; maintaining a desired water balance by moving water in or out of a substrate; hydration; wetting agents; coatings; stents; bandages JOHNSON & JOHNSON VISION CAR, INC 2008-05-15 US disclosed
US-20080103231-A1 PROCESS FOR FORMING CLEAR, WETTABLE SILICONE HYDROGEL ARTICLES JOHNSON & JOHNSON VISION CARE, INC. 2008-05-01 US disclosed
US-20070222095-A1 PROCESS FOR MAKING OPHTHALMIC LENSES JOHNSON & JOHNSON VISION CARE, INC. 2007-09-27 US disclosed
US-20070222094-A1 Process for making ophthalmic lenses JOHNSON & JOHNSON VISION CARE, INC. 2007-09-27 US disclosed