Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.48 |
| ▸ | VNN1 | O95497 | 1/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10076237 | 1.00 | CYP11B2 (0.51) | CYP11B2MGLLKMT2AMEN1CYP1A2 | |
| SCHEMBL1912094 | 0.96 | SLC6A7 (0.53) | CYP11B2MGLLKMT2AMEN1CYP1A2 | |
| SCHEMBL10076236 | 0.91 | GRM5 (0.56) | MGLLKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL17850465 | 0.87 | ALDH1A1 (0.48) | MGLLKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL18616788 | 0.85 | CYP11B2 (0.48) | CYP11B2KMT2AHDAC4GRM3VNN1 | |
| SCHEMBL13920471 | 0.85 | LOXL2 (0.51) | CYP11B2KMT2AHDAC4GRM3VNN1 | |
| SCHEMBL13920470 | 0.85 | LOXL2 (0.51) | CYP11B2KMT2AHDAC4GRM3VNN1 | |
| SCHEMBL12309795 | 0.85 | KMT2A (0.57) | MGLLKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL12510763 | 0.84 | CYP11B2 (0.48) | CYP11B2KMT2AHDAC4GRM3VNN1 | |
| SCHEMBL9906900 | 0.84 | VNN1 (0.50) | CYP11B2KMT2AHDAC4GRM3VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | CYP11B2 190/4885MGLL 4369/4885KMT2A 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.