Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 9/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12583936 | 0.89 | SIRT1 (0.47) | SIRT1SIRT6SIRT2SIRT3HDAC4 | |
| SCHEMBL2607891 | 0.89 | SIRT1 (0.44) | SIRT1SIRT6SIRT2SIRT3HDAC4 | |
| SCHEMBL14870358 | 0.88 | SIRT2 (0.49) | SIRT1SIRT6SIRT2SIRT3HDAC4 | |
| SCHEMBL13311516 | 0.88 | SIRT2 (0.45) | SIRT1SIRT6SIRT2SIRT3HDAC4 | |
| SCHEMBL277854 | 0.87 | SIRT2 (0.48) | SIRT1SIRT6SIRT2SIRT3HDAC4 | |
| SCHEMBL13498644 | 0.85 | EPHX1 (0.53) | SIRT1SIRT6SIRT2SIRT3 | |
| SCHEMBL25176589 | 0.85 | KMT2A (0.45) | SIRT1SIRT2SIRT3ACHE | |
| SCHEMBL25176590 | 0.85 | KMT2A (0.45) | SIRT1SIRT2SIRT3ACHE | |
| SCHEMBL2607889 | 0.85 | SIRT2 (0.45) | SIRT1SIRT6SIRT2SIRT3HDAC4 | |
| SCHEMBL15975505 | 0.84 | TGM2 (0.48) | SIRT1SIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170035898-A1 | CONJUGATES OF AN IL-15 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS | 2017-02-09 | — | — | US | disclosed |
| US-9101670-B2 | Conjugates of an anti-TNF-α antibody | NEKTAR THERAPEUTICS (US) | 2015-08-11 | — | — | US | disclosed |
| US-20140044672-A1 | CONJUGATES OF A GM-CSF MOIETY AND A POLYMER | NEKTAR THERAPEUTICS (US) | 2014-02-13 | — | — | US | disclosed |
| US-20130096258-A1 | POLYMER CONJUGATES OF GLP-1 | NEKTAR THERAPEUTICS (US) | 2013-04-18 | — | — | US | disclosed |
| US-8293869-B2 | Polymer conjugates of GLP-1 | NEKTAR THERAPEUTICS (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110171161-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171163-A1 | POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110165113-A1 | POLYMER CONJUGATES OF V681-LIKE PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166063-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-07 | — | — | US | disclosed |
| US-20100210505-A1 | POLYMER CONJUGATES OF GLP-1 | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2010-08-19 | — | — | US | disclosed |
| US-20100021481-A1 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY | NEKTAR THERAPEUTICS (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171163-A1 | POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES | NGLY1, VIP, IAPP | SIRT1 1782/4885SIRT6 2987/4885SIRT2 2999/4885 |
| US-20100021481-A1 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY | TNF, TNFRSF1A, TNFRSF9 | SIRT1 3698/4885SIRT6 2713/4885SIRT2 4104/4885 |
| US-20100210505-A1 | POLYMER CONJUGATES OF GLP-1 | GLP1R, GIPR, NGLY1 | SIRT1 105/4885SIRT6 370/4885SIRT2 670/4885 |
| US-20130096258-A1 | POLYMER CONJUGATES OF GLP-1 | GLP1R, GIPR, NGLY1 | SIRT1 74/4885SIRT6 291/4885SIRT2 629/4885 |
| US-20110171161-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | PSMG3, PSMB11, PSMC5 | SIRT1 2889/4885SIRT6 2901/4885SIRT2 2910/4885 |
| US-20110166063-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | SIRT1 3118/4885SIRT6 3067/4885SIRT2 3408/4885 |
| US-20140044672-A1 | CONJUGATES OF A GM-CSF MOIETY AND A POLYMER | CSF3R, GMFG, CSF1R | SIRT1 3359/4885SIRT6 3152/4885SIRT2 3614/4885 |
| US-20110165113-A1 | POLYMER CONJUGATES OF V681-LIKE PEPTIDES | NGLY1, VIP, DNPEP | SIRT1 4504/4885SIRT6 3636/4885SIRT2 4713/4885 |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | DNPEP, VIP, PTMS | SIRT1 3361/4885SIRT6 3792/4885SIRT2 4150/4885 |
| US-20170035898-A1 | CONJUGATES OF AN IL-15 MOIETY AND A POLYMER | IL15, IL15RA, IL2 | SIRT1 2294/4885SIRT6 2939/4885SIRT2 2813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.