Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2192508 | 0.89 | RXFP1 (0.52) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL1258627 | 0.84 | GABRA1 (0.58) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL31058084 | 0.84 | GABRA1 (0.58) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL7403266 | 0.76 | GABRA1 (0.50) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL7478081 | 0.75 | RXFP1 (0.52) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL12416458 | 0.75 | GABRA1 (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12416453 | 0.75 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7479574 | 0.74 | RXFP1 (0.56) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL21362800 | 0.74 | GABRG2 (0.50) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL7482551 | 0.73 | RXFP1 (0.49) | RXFP1L3MBTL1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140024652-A1 | SUBSTITUTED TRIAZOLOPHTHALAZINE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2014-01-23 | — | — | US | disclosed |
| US-8557815-B2 | Substituted triazolophthalazine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20110172235-A1 | SUBSTITUTED TRIAZOLOPHTHALAZINE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172235-A1 | SUBSTITUTED TRIAZOLOPHTHALAZINE DERIVATIVES | GPR55, HTR5A, GRK5 | RXFP1 361/4885L3MBTL1 4074/4885GABRA1 155/4885 |
| US-20140024652-A1 | SUBSTITUTED TRIAZOLOPHTHALAZINE DERIVATIVES | GPR55, HTR5A, GRK5 | RXFP1 361/4885L3MBTL1 4074/4885GABRA1 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.