Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.47 |
| ▸ | MTOR | P42345 | 5/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726078 | 0.83 | ALDH1A1 (0.65) | PIK3CDPIK3CBPIK3CGMTORPIK3C3 | |
| SCHEMBL2195206 | 0.82 | CCR2 (0.46) | SMN1; SMN2MAPK1TP53PKMALOX15 | |
| SCHEMBL2195213 | 0.82 | CCR2 (0.46) | SMN1; SMN2MAPK1TP53PKMALOX15 | |
| SCHEMBL12418316 | 0.81 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CGMTORPIK3C3 | |
| SCHEMBL1723222 | 0.78 | UCHL1 (0.54) | PIK3CDPIK3CBPIK3CGMTORPIK3C3 | |
| SCHEMBL9015423 | 0.78 | KDM4E (0.58) | SMN1; SMN2MAPK1ALDH1A1CYP3A4TSHR | |
| SCHEMBL17205724 | 0.78 | ALDH1A1 (0.71) | SMN1; SMN2ALDH1A1CYP3A4TSHRKDM4E | |
| SCHEMBL13812157 | 0.78 | ALDH1A1 (0.71) | SMN1; SMN2ALDH1A1CYP3A4TSHRKDM4E | |
| SCHEMBL2192659 | 0.78 | L3MBTL1 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL2192662 | 0.78 | L3MBTL1 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435968-B2 | Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use | PIMCO 2664 LIMITED (GB) | 2013-05-07 | — | — | US | disclosed |
| US-20110172189-A1 | Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use | PIMCO 2664 LIMITED (GB) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172189-A1 | Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use | SOST, AADAC, ARSA | PIK3CD 1335/4885PIK3CB 1336/4885PIK3CG 1710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.