Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 7/20 | 0.81 |
| ▸ | CA1 | P00915 | 15/20 | 0.69 |
| ▸ | CA2 | P00918 | 15/20 | 0.69 |
| ▸ | CA12 | O43570 | 14/20 | 0.69 |
| ▸ | CA9 | Q16790 | 13/20 | 0.69 |
| ▸ | CA6 | P23280 | 12/20 | 0.69 |
| ▸ | CA7 | P43166 | 12/20 | 0.69 |
| ▸ | CA14 | Q9ULX7 | 12/20 | 0.69 |
| ▸ | CA5B | Q9Y2D0 | 11/20 | 0.69 |
| ▸ | CA3 | P07451 | 11/20 | 0.69 |
| ▸ | CA13 | Q8N1Q1 | 11/20 | 0.69 |
| ▸ | CA5A | P35218 | 10/20 | 0.69 |
| ▸ | CA4 | P22748 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.57 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1716052 | 0.90 | CISD1 (1.00) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL12418659 | 0.82 | CISD1 (0.83) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL13545223 | 0.81 | CISD1 (0.80) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL18424857 | 0.81 | CA1 (1.00) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL31670531 | 0.81 | CA1 (1.00) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL18425099 | 0.81 | CISD1 (0.78) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL13543235 | 0.81 | CISD1 (0.78) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL10963208 | 0.80 | CISD1 (0.70) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL11816758 | 0.80 | CISD1 (0.77) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL11874599 | 0.79 | CISD1 (0.72) | CISD1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9248131-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2016-02-02 | — | — | US | disclosed |
| US-9248131-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150224108-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | UNIV ARIZONA STATE (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150224108-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | UNIV ARIZONA STATE (US) | 2015-08-13 | — | — | US | disclosed |
| US-8835491-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835491-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2014-09-16 | — | — | US | disclosed |
| EP-2086329-B1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | UNIV ARIZONA STATE (US) | 2014-07-23 | — | — | EP | disclosed |
| US-20110172195-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110172195-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) | 2011-07-14 | — | — | US | disclosed |
| US-7906555-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2011-03-15 | — | — | US | disclosed |
| US-7906555-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2011-03-15 | — | — | US | disclosed |
| US-20080221169-A1 | 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels; brain trauma, head trauma, eye disorder, pulmonary disorder, lung disease, vascular disease, kidney disease, heavy metal toxicity, Alzheimer's disease, tumor, and cancer | ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) | 2008-09-11 | — | — | US | disclosed |
| US-20080221169-A1 | 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels; brain trauma, head trauma, eye disorder, pulmonary disorder, lung disease, vascular disease, kidney disease, heavy metal toxicity, Alzheimer's disease, tumor, and cancer | ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221169-A1 | 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels; brain trauma, head trauma, eye disorder, pulmonary disorder, lung disease, vascular disease, kidney disease, heavy metal toxicity, Alzheimer's disease, tumor, and cancer | AQP4, AQP3, AQP1 | CISD1 1076/4885CA1 223/4885CA2 12/4885 |
| US-20150224108-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | AQP1, AQP4, AQP3 | CISD1 2335/4885CA1 1196/4885CA2 168/4885 |
| US-20110172195-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | AQP1, AQP4, AQP3 | CISD1 2335/4885CA1 1196/4885CA2 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.