Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | DBH | P09172 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121174 | 0.92 | KDM4E (0.62) | KDM4EDBHGAARECQLPDPK1 | |
| SCHEMBL2625198 | 0.91 | SMN1; SMN2 (0.61) | KDM4EGAASMN1; SMN2LMNAHTT | |
| SCHEMBL13203107 | 0.91 | HSD17B1 (0.59) | KDM4EDBHGAARECQLPDPK1 | |
| SCHEMBL11307780 | 0.89 | CES2 (0.48) | KDM4EDBHGAARECQLPDPK1 | |
| SCHEMBL22548943 | 0.89 | KDM4E (0.52) | KDM4EDBHGAARECQLPDPK1 | |
| SCHEMBL2918747 | 0.89 | CES2 (0.48) | KDM4EDBHGAARECQLPDPK1 | |
| SCHEMBL25139482 | 0.87 | HDAC1 (0.53) | KDM4EDBHGAARECQLPDPK1 | |
| SCHEMBL678080 | 0.85 | CES2 (0.55) | ALDH1A1RXRA | |
| SCHEMBL10941943 | 0.84 | KDM4E (0.56) | KDM4EDBHGAARECQLSMN1; SMN2 | |
| SCHEMBL24814137 | 0.84 | HDAC3 (0.47) | KDM4EDBHGAARECQLPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200323814-A1 | MEDICAL COMPOUND | VERA SALUS RICERCA S.R.L. (IT) | 2020-10-15 | — | — | US | disclosed |
| US-20110171171-A1 | BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS, INC. (CA) | 2011-07-14 | — | — | US | disclosed |
| US-20100203012-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS, INC. (CA) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100203012-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC3 | KDM4E 4223/4885DBH 4079/4885GAA 2614/4885 |
| US-20200323814-A1 | MEDICAL COMPOUND | MTNR1B, CBR1, MTNR1A | KDM4E 3339/4885DBH 442/4885GAA 3330/4885 |
| US-20110171171-A1 | BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC7 | KDM4E 3173/4885DBH 2518/4885GAA 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.