Sugi Predict

Sugi Predict / Compounds / SCHEMBL12419259

SCHEMBL12419259

SCHEMBL12419259

OB(O)c1ccc2cc(Oc3cnccn3)ccc2c1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.47
▸ KMT2A Q03164 2/20 0.45
▸ CA1 P00915 1/20 0.42
▸ CA2 P00918 1/20 0.42
▸ HRH3 Q9Y5N1 1/20 0.41
▸ LTA4H P09960 1/20 0.40
▸ PTGS2 P35354 1/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ PLAU P00749 1/20 0.38
▸ MAPT P10636 3/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ SLC6A2 P23975 2/20 0.36
▸ SLC6A4 P31645 2/20 0.36
▸ SLC6A3 Q01959 2/20 0.36
▸ GCK P35557 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12419258 0.81 CA1 (0.51) KDM4ECA1CA2HRH3LTA4H
SCHEMBL5687538 0.80 KDM4E (0.50) KDM4EKMT2AHRH3LTA4HPTGS2
SCHEMBL12419260 0.75 RAB9A (0.58) KDM4EKMT2ACA1CA2HRH3
SCHEMBL29956276 0.72 CA1 (0.55) CA1CA2MAPT
SCHEMBL1519997 0.72 CA1 (0.55) CA1CA2MAPT
SCHEMBL5317075 0.71 KDM4E (0.62) KDM4EKMT2AHRH3LTA4HPTGS2
Hydrochloric Acid SCHEMBL29954115 0.71 CA1 (0.53) CA1CA2MAPT
Hydrochloric Acid SCHEMBL1519681 0.71 CA1 (0.53) CA1CA2MAPT
SCHEMBL17423765 0.71 KMT2A (0.49) KDM4EKMT2AHRH3LTA4HPTGS2
SCHEMBL3721066 0.70 KDM4E (0.49) KDM4EKMT2AHRH3LTA4HPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
WO-2009126691-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC (US) 2009-10-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 KDM4E 1442/4885KMT2A 2097/4885CA1 822/4885
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 KDM4E 1442/4885KMT2A 2097/4885CA1 822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.