Sugi Predict

Sugi Predict / Compounds / SCHEMBL12419461

SCHEMBL12419461

SCHEMBL12419461

OB(O)c1cccc(-c2nnc(-c3ccccc3)o2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 1/20 0.61
▸ NPC1 O15118 16/20 0.59
▸ RAB9A P51151 16/20 0.59
▸ SMN1; SMN2 Q16637 9/20 0.59
▸ TSHR P16473 5/20 0.57
▸ HPGD P15428 4/20 0.57
▸ TP53 P04637 2/20 0.57
▸ NFKB1 P19838 2/20 0.57
▸ NFKB2 Q00653 2/20 0.57
▸ RELA Q04206 2/20 0.57
▸ MECP2 P51608 1/20 0.57
▸ CA1 P00915 1/20 0.54
▸ CA2 P00918 1/20 0.54
▸ CA9 Q16790 1/20 0.54
▸ CA13 Q8N1Q1 1/20 0.54
▸ ALDH1A1 P00352 5/20 0.50
▸ MAPT P10636 2/20 0.50
▸ ATAD2 Q6PL18 1/20 0.50
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2816834 0.84 NPC1 (0.65) MGLLNPC1RAB9ASMN1; SMN2TSHR
SCHEMBL30905979 0.83 MGLL (0.49) MGLLNPC1RAB9ASMN1; SMN2TSHR
SCHEMBL782120 0.83 MGLL (0.49) MGLLNPC1RAB9ASMN1; SMN2TSHR
SCHEMBL14378791 0.81 NPC1 (0.81) NPC1RAB9ASMN1; SMN2TSHRHPGD
SCHEMBL12306757 0.79 NPC1 (0.77) NPC1RAB9ASMN1; SMN2TSHRHPGD
SCHEMBL12420280 0.79 MAOA (0.52) MGLLNPC1RAB9ASMN1; SMN2TSHR
SCHEMBL12419583 0.79 RAB9A (0.67) NPC1RAB9ASMN1; SMN2TSHRHPGD
SCHEMBL12419582 0.79 RAB9A (0.49) NPC1RAB9ASMN1; SMN2TSHRHPGD
SCHEMBL12420279 0.78 NPC1 (0.69) NPC1RAB9ASMN1; SMN2TSHRHPGD
SCHEMBL10493895 0.77 NPC1 (0.74) NPC1RAB9ASMN1; SMN2TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
WO-2009126691-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC (US) 2009-10-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 MGLL 15/4885NPC1 472/4885RAB9A 1820/4885
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 MGLL 15/4885NPC1 472/4885RAB9A 1820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.