Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.64 |
| ▸ | CES1 | P23141 | 3/20 | 0.64 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | GAPDH | P04406 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242175 | 0.87 | CES2 (0.55) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL1802680 | 0.82 | NSD2 (0.73) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL17594744 | 0.82 | NSD2 (0.47) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL19409308 | 0.79 | MAOA (0.56) | NSD2HSP90AA1HKDC1TLR9ALDH1A1 | |
| SCHEMBL17594373 | 0.79 | CES2 (0.64) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL17594549 | 0.79 | CES2 (0.64) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL17594366 | 0.79 | LTA4H (0.56) | NSD2HSP90AA1HKDC1TLR9ALDH1A1 | |
| SCHEMBL1804265 | 0.79 | NSD2 (0.49) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL13879151 | 0.79 | NSD2 (0.49) | CES2CES1NSD2HSP90AA1HKDC1 | |
| SCHEMBL12767607 | 0.76 | NSD2 (0.55) | CES2CES1NSD2HSP90AA1HKDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472315-B2 | Inhibitors of methionine aminopeptidases and methods of treating disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-11-12 | — | — | US | disclosed |
| US-20120196852-A1 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-02 | — | — | US | disclosed |
| WO-2011017519-A2 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196852-A1 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS | METAP1, METAP2, ENPEP | CES2 1371/4885CES1 811/4885NSD2 1217/4885 |
| US-10472315-B2 | Inhibitors of methionine aminopeptidases and methods of treating disorders | METAP1, METAP2, ENPEP | CES2 1371/4885CES1 811/4885NSD2 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.